Journal ArticleDOI
The role of cyclic AMP response element binding protein in transactivation of scavenger receptor class B type I promoter in transfected cells and in primary cultures of rat theca-interstitial cells.
Roberto Towns,K.M.J. Menon +1 more
TLDR
Data indicate that stimulation of the cAMP-PKA-CREB pathway enhances rat SR-BIpr activity and substantiate the role of CREB as an intermediary in this process.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2005-12-21. It has received 12 citations till now. The article focuses on the topics: CREB & Cyclic AMP Response Element.read more
Citations
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Journal ArticleDOI
SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer.
TL;DR: The role of SR-BI during tumor development and malignant progression is discussed and insights into the transcriptional and post-transcriptional regulation of the SCARB1 gene are provided.
increases the severity of polycystic ovary formation in vivo
TL;DR: It is reported that aged mice specifically lacking the PKBβ (also known as Akt2) isoform that is crucial for insulin signaling develop increased testosterone levels and ovarian cysts, both of which are also observed in insulin-resistant PCOS patients.
Journal ArticleDOI
Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport
TL;DR: This review aims to summarize the current knowledge of HDL- and apoA-I -induced signal transduction pathways that are linked to cholesterol efflux and discusses the underlying mechanisms that could couple ligand binding to SR-BI and ABCA1 with signaling and cholesterol export.
Journal ArticleDOI
Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo
TL;DR: In this paper, the effects of deregulated insulin signaling in the ovary is considered an important factor in the development of polycystic ovarian syndrome (PCOS), which can result in infertility.
Journal ArticleDOI
SR-BI as a target of natural products and its significance in cancer.
Dongdong Wang,Jiansheng Huang,Ting Gui,Yaxin Yang,Tingting Feng,Nikolay T. Tzvetkov,Tao Xu,Zhibo Gai,Ying Zhou,Jingjie Zhang,Atanas G. Atanasov +10 more
TL;DR: The purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulatingSR-BI expression, as well as to provide an overview of natural products that regulate SR- BI expression.
References
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PatentDOI
Measurement of protein using bicinchoninic acid
TL;DR: This new method maintains the high sensitivity and low protein-to-protein variation associated with the Lowry technique and demonstrates a greater tolerance of the bicinchoninate reagent toward such commonly encountered interferences as nonionic detergents and simple buffer salts.
Journal ArticleDOI
A receptor-mediated pathway for cholesterol homeostasis.
TL;DR: The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.
Journal ArticleDOI
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Susan L. Acton,Attilio Rigotti,Katherine T. Landschulz,Shangzhe Xu,Helen H. Hobbs,Monty Krieger +5 more
TL;DR: It is shown that the class B scavenger receptor SR-BI is an HDL receptor, which mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.
Journal ArticleDOI
An Improved Diphenylamine Method for the Estimation of Deoxyribonucleic Acid
K. W. Giles,A. Myers +1 more
TL;DR: In this article, the Burton diphenylamine method was used to estimate extreme sensitivity coupled with a low reagent blank, which was simplified and the blank considerably reduced and the sensitivity increased.
Journal ArticleDOI
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Stephan Herzig,Fanxin Long,Fanxin Long,Ulupi S. Jhala,Susan Hedrick,Rebecca Quinn,Anton Bauer,Dorothea Rudolph,Günther Schütz,Cliff H. Yoon,Pere Puigserver,Bruce M. Spiegelman,Marc Montminy +12 more
TL;DR: Fasting hyperglycaemia* is strongly correlated with type II diabetes, so the results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease.
Related Papers (5)
CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines.
K M Piech-Dumas,A W Tank +1 more