Journal ArticleDOI
The Roles of Serotonin in Neuropsychiatric Disorders.
Mahsa Pourhamzeh,Fahimeh Ghasemi Moravej,Mehrnoosh Arabi,Mehrnoosh Arabi,Elahe Shahriari,Soraya Mehrabi,Richard T. Ward,Reza Ahadi,Mohammad Taghi Joghataei +8 more
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TLDR
The serotonergic system extends throughout the central nervous system (CNS) and the gastrointestinal (GI) tract, including mood, cognition, anxiety, learning, memory, reward processing, and sleep as discussed by the authors.Abstract:
The serotonergic system extends throughout the central nervous system (CNS) and the gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a broad spectrum of functions, including mood, cognition, anxiety, learning, memory, reward processing, and sleep. These processes are mediated through 5-HT binding to 5-HT receptors (5-HTRs), are classified into seven distinct groups. Deficits in the serotonergic system can result in various pathological conditions, particularly depression, schizophrenia, mood disorders, and autism. In this review, we outlined the complexity of serotonergic modulation of physiologic and pathologic processes. Moreover, we provided experimental and clinical evidence of 5-HT's involvement in neuropsychiatric disorders and discussed the molecular mechanisms that underlie these illnesses and contribute to the new therapies.read more
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Journal ArticleDOI
Increased efficacy of combining prebiotic and postbiotic in mouse models relevant to autism and depression.
Antonio Leo,Carmen De Caro,P. Mainardi,Martina Tallarico,Valentina Nesci,Nadia Marascio,Pasquale Striano,Emilio Russo,Andrew Constanti,Giovambattista De Sarro,Rita Citraro +10 more
TL;DR: In this paper, the effects of α-lactalbumin (ALAC), a prebiotic in the dose range of 125-500mg/kg, and sodium butyrate (NaB) alone and in combination were investigated for idiopathic autism and anxiety/depression.
Journal ArticleDOI
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders.
TL;DR: In this article, a new generation of highly selective, efficacious and druggable biased agonists have been identified which exhibit increased affinity at 5-HT1A receptors and new profiles of cellular signaling bias, notably for β-arrestin recruitment versus pERK.
Journal ArticleDOI
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders
TL;DR: In this paper , a new generation of highly selective, efficacious and druggable 5-HT1A receptor biased agonists have been identified, which have shown differential properties for G-protein signaling, cellular signaling, electrophysiological effects, neurotransmitter release, neuroimaging by PET and pharmacoMRI, and behavioral tests of mood, motor activity and side effects.
Journal ArticleDOI
The Effects of Statins on Neurotransmission and Their Neuroprotective Role in Neurological and Psychiatric Disorders.
Michał Kosowski,Joanna Smolarczyk-Kosowska,Marcin Hachuła,Mateusz Maligłówka,Marcin Basiak,Grzegorz Machnik,Robert Pudlo,Bogusław Okopień +7 more
TL;DR: A review of the literature describing the impacts of statins on dopamine, serotonin, acetylcholine, and glutamate neurotransmission, as well as their neuroprotective role is presented in this paper.
Journal ArticleDOI
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders.
Heather J. Walter,A. Reese Abright,Oscar G. Bukstein,John Diamond,Helene Keable,Jane Ripperger-Suhler,Carol M. Rockhill +6 more
TL;DR: In this article , the authors present evidence-based guidance about the psychosocial and psychopharmacologic treatment of major depressive disorder (MDD) and persistent depressive disorder in children and adolescents.
References
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Journal ArticleDOI
Effects of 5-HT5A receptor blockade on amnesia or forgetting.
TL;DR: The present findings are consistent with the notion that low doses of 5‐HT5A receptor antagonists might be useful for reversing memory deficits associated to forgetting and amnesia and Nose‐poke seems to be a reliable operandum.
Journal ArticleDOI
Circadian rhythms of clock gene expression in the cerebellum of serotonin-deficient Pet-1 knockout mice.
Erin V. Paulus,Eric M. Mintz +1 more
TL;DR: The results suggest that serotonin is not an important mediator of circadian rhythms in the cerebellum in a way that parallels its regulation of the circadian clock in the suprachiasmatic nucleus.
Journal ArticleDOI
Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy
TL;DR: Serotonin has a unique ability to touch on each of the processes that may be required to recover from hypoxic reflex apnea: gasping, the restoration of heart rate and blood pressure, termination of apneas and, eventually, stimulation of eupnea and arousal are all modulated by serotonin.
Journal ArticleDOI
Serotonin induces Arcadlin in hippocampal neurons
Hidekazu Tanaka,Toshinori Sawano,Naoko Konishi,Risako Harada,Chiaki Takeuchi,Yuki Shin,Hiroko Sugiura,Jin Nakatani,Takahiro Fujimoto,Kanato Yamagata +9 more
TL;DR: The data indicate that the Arcadlin-p38 MAP kinase pathway is a candidate neural network modulator that is activated in hippocampal neurons under the dual regulation of serotonin and glutamate and, hence, may play a role in antidepressant therapies.
Book ChapterDOI
Chronic Migraine: Diagnosis and Management
Roger Cady,Paul L. Durham +1 more
TL;DR: It is explained how lifestyle, behavior, diet, and the physical environment may influence the progression or remission of migraine, making complementary interventions central to effective management of CM.