Journal ArticleDOI
The same but different: the biology of Theileria sporozoite entry into bovine cells
TLDR
It is suggested that the initial sporozoite binding event triggers the mobilization of intrasporozoite Ca2+ and the activation of both kinase and G-protein associated signalling processes in the parasite, which regulate the invasive capacity of the sporozoites.About:
This article is published in International Journal for Parasitology.The article was published on 1997-05-01. It has received 53 citations till now. The article focuses on the topics: Theileria & Theileria parva.read more
Citations
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Journal ArticleDOI
Cytoskeleton of Apicomplexan Parasites
TL;DR: The unusual properties of actin and myosin in the Apicomplexa, the highly stereotyped microtubule populations in apicOMplexans, and a network of recently discovered novel intermediate filament-like elements in these parasites are discussed.
Journal ArticleDOI
Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
TL;DR: Key parameters in T. parva population dynamics are the relative importance of asymptomatic carrier cattle and animals undergoing severe disease, in transmission of the parasite to ticks, and the extent of transmission by nymphs as compared to adult ticks.
Book ChapterDOI
Microneme Proteins in Apicomplexans
TL;DR: Structural and biochemical analyses of MIC domains is providing new perspectives on how adhesion is regulated and the potentially distinct roles MICs might play in long or short range interactions during parasite attachment and entry.
Journal ArticleDOI
Inhibition of apoptosis by intracellular protozoan parasites
TL;DR: Two families of molecules, which are known for their capacity to interrupt the apoptotic program, are currently discussed in the literature and can directly interfere with molecules of the cellular death machinery.
Journal ArticleDOI
Transformation of Leukocytes by Theileria parva and T. annulata
TL;DR: The presence of the parasite in the host-cell cytoplasm modulates the state of activation of a number of signal transduction pathways, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells.
References
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Journal ArticleDOI
Phagolysosomal escape by intracellular pathogens
Norma W. Andrews,Paul Webster +1 more
TL;DR: The information available on strategies for phagolysosomal escape of pathogens ranging from bacteria to protozoa is discussed, with emphasis on the cases in which the molecular mechanisms controlling this event have been investigated.
Journal ArticleDOI
Theileria annulata sporozoite surface antigen (SPAG-1) contains neutralizing determinants in the C terminus
Nicky Boulter,Pamela Knight,Philip D. Hunt,Emma S. Hennessey,Frank Katzer,Andrew Tait,Susanna Williamson,Duncan Brown,Howard A. Baylis,Roger Hall +9 more
TL;DR: SPAG‐1 is a surface antigen on Theileria annulata sporozoites that is a candidate both for inclusion in a subunit vaccine and as a ligand for host cell recognition and the implications for sub‐unit vaccine production are discussed.
Journal ArticleDOI
Divalent cation and ATP dependent motility of Toxoplasma gondii tachyzoites after mild treatment with trypsin.
TL;DR: The present preparation, which provided the first serial illustrations of T. gondii movements induced by a defined chemical stimulus, may offer a useful experimental model for the study of motility in this parasite.
Book ChapterDOI
The Biology of Theileria Species in Ixodid Ticks in Relation to Parasite Transmission
Michael K. Shaw,Alan S. Young +1 more
TL;DR: The dynamics of transmission of Theileria species by ixodid ticks are considered, restricted mainly to T. parva species of cattle and in particular T. annulata.
Journal ArticleDOI
Differential development and emission of Theileria parva sporozoites from the salivary gland of Rhipicephalus appendiculatus
M. K. Shaw,A. S. Young +1 more
TL;DR: The initiation of feeding of infected Rhipicephalus appendiculatus adults induces the rapid development of Theileria parva sporoblasts within the salivary gland acini leading to the production of numerous sporozoites which are inoculated into the mammalian host initiating infection.