Journal ArticleDOI
Cell invasion by Theileria sporozoites.
TLDR
This article highlights some of the differences in sporozoite entry with the entry processes of other Theileria life cycle stages, and compares them with other apicomplexans such as Plasmodium and Toxoplasma.About:
This article is published in Trends in Parasitology.The article was published on 2003-01-01. It has received 133 citations till now. The article focuses on the topics: Theileria.read more
Citations
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Journal ArticleDOI
The dormant blood microbiome in chronic, inflammatory diseases
TL;DR: Overall, it seems that many more chronic, non-communicable, inflammatory diseases may have a microbial component than are presently considered, and may be treatable using bactericidal antibiotics or vaccines.
Journal ArticleDOI
The moving junction of apicomplexan parasites: a key structure for invasion.
TL;DR: An emerging model emphasizes a cooperative role of secreted parasitic proteins in building the moving junction and driving this crucial invasive process of the parasite into a parasitophorous vacuole.
Journal ArticleDOI
Invasion and intracellular survival by protozoan parasites
TL;DR: Intracellular parasitism has arisen only a few times during the long ancestry of protozoan parasites including in diverse groups such as microsporidians, kinetoplastids, and apicomplexans and may identify key steps that can be targeted to reduce parasite survival or augment immunologic responses and thereby prevent disease.
Journal ArticleDOI
Toxoplasma gondii Targets a Protein Phosphatase 2C to the Nuclei of Infected Host Cells
Luke A. Gilbert,Sandeep Ravindran,Jay M. Turetzky,John C. Boothroyd,Peter J. Bradley,Peter J. Bradley +5 more
TL;DR: The delivery of parasite effector proteins via the rhoptries provides a novel mechanism for Toxoplasma to directly access the command center of its host cell during infection by the parasite.
Journal ArticleDOI
Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
Simon P. Graham,Roger Pelle,Yoshikazu Honda,Duncan Mwangi,Nyerhovwo J. Tonukari,Mat Yamage,E. Jane Glew,Etienne P. de Villiers,Trushar Shah,Richard P. Bishop,Evelyne Abuya,Elias Awino,James Gachanja,Anthony E. Luyai,Ferdinand Mbwika,Anthony M. Muthiani,David Ndegwa,Moses N. Njahira,John K. Nyanjui,Fredrick O. Onono,Julius Osaso,Rosemary Saya,Claude Wildmann,Claire M. Fraser,Ian Maudlin,Malcolm J. Gardner,Subhash Morzaria,Sheena M. Loosmore,Sarah C. Gilbert,J.C. Audonnet,Pierre van der Bruggen,Vishvanath Nene,Evans L. N. Taracha +32 more
TL;DR: The identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8(+) CTL from immune cattle provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine and orthologs of these antigen may be vaccine targets for other apicomplexan parasites.
References
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Journal Article
Sequential protein secretion from three distinct organelles of toxoplasma gondii accompanies invasion of human fibroblasts
Vern B. Carruthers,L D Sibley +1 more
TL;DR: Compared the kinetics of secretion from these different compartments during host cell invasion using immunofluorescence, immunoelectron microscopy, and quantitative immunoassays, it is suggested that their release is governed by separate signals and that their contents mediate distinct phases of intracellular parasitism.
Book
The epidemiology of theileriosis in Africa
TL;DR: The contents of this book span from the fascinating 'whodunit' detective work of early investigators in the 1900s to the control methods listed in Chapter II that offer the potential to 'undo it', and the two final chapters on modeling and economic impact acknowledge the broad perspective in which efforts to control the disease are now set.
Journal ArticleDOI
Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation.
TL;DR: A method for blocking invasion at an early stage in the sequence of invasion of erythrocytes by malaria merozoites is described, although these RBCs are resistant to invasion by the parasite.
Journal ArticleDOI
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole.
TL;DR: It is indicated that a two‐step process involving direct rhoptry secretion into the host cell cytoplasm followed by incorporation into the vacuole generates the parasitophorous vacuoles occupied by Toxoplasma.
Journal ArticleDOI
The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells
Klaus Lingelbach,Keith A. Joiner +1 more
TL;DR: It is concluded that most differences between the organisms primarily reflect the different biosynthetic capacities of the host cells they invade.
Related Papers (5)
Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes.
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