Journal ArticleDOI
The same but different: the biology of Theileria sporozoite entry into bovine cells
TLDR
It is suggested that the initial sporozoite binding event triggers the mobilization of intrasporozoite Ca2+ and the activation of both kinase and G-protein associated signalling processes in the parasite, which regulate the invasive capacity of the sporozoites.About:
This article is published in International Journal for Parasitology.The article was published on 1997-05-01. It has received 53 citations till now. The article focuses on the topics: Theileria & Theileria parva.read more
Citations
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Journal ArticleDOI
Cytoskeleton of Apicomplexan Parasites
TL;DR: The unusual properties of actin and myosin in the Apicomplexa, the highly stereotyped microtubule populations in apicOMplexans, and a network of recently discovered novel intermediate filament-like elements in these parasites are discussed.
Journal ArticleDOI
Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
TL;DR: Key parameters in T. parva population dynamics are the relative importance of asymptomatic carrier cattle and animals undergoing severe disease, in transmission of the parasite to ticks, and the extent of transmission by nymphs as compared to adult ticks.
Book ChapterDOI
Microneme Proteins in Apicomplexans
TL;DR: Structural and biochemical analyses of MIC domains is providing new perspectives on how adhesion is regulated and the potentially distinct roles MICs might play in long or short range interactions during parasite attachment and entry.
Journal ArticleDOI
Inhibition of apoptosis by intracellular protozoan parasites
TL;DR: Two families of molecules, which are known for their capacity to interrupt the apoptotic program, are currently discussed in the literature and can directly interfere with molecules of the cellular death machinery.
Journal ArticleDOI
Transformation of Leukocytes by Theileria parva and T. annulata
TL;DR: The presence of the parasite in the host-cell cytoplasm modulates the state of activation of a number of signal transduction pathways, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells.
References
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Journal ArticleDOI
Proteins on the surface of the malaria parasite and cell invasion.
TL;DR: The malaria parasite exists in an extracellular form at several stages in its life cycle and sporozoites and merozoites have to invade specific cell types within the vertebrate host.
Journal ArticleDOI
Theileria annulata sporozoite surface antigen expressed in Escherichia coli elicits neutralizing antibody.
Susanna Williamson,Andrew Tait,Duncan Brown,Alan W. Walker,Peter Beck,Brian Shiels,June D. Fletcher,Roger Hall +7 more
TL;DR: A surface antigen complex of the infective stage (sporozoite), by using a monoclonal antibody that neutralizes sporozoite infectivity in vitro, is characterized and cloned the gene coding for this complex is cloned and it is demonstrated that a fusion protein expressed from a fragment of this gene elicits strong neutralizing antibodies.
Journal ArticleDOI
Invasion of vertebrate cells by Toxoplasma gondii.
TL;DR: Toxoplasma gondii actively invades its host cell rather than entering by conventional phagocytosis, powered by a microfilament-based motility system in the parasite that leads to invagination of the host cell plasma membrane to form a novel intracellular vacuole.
Journal ArticleDOI
The role of Ca2+ in the process of cell invasion by intracellular parasites.
TL;DR: Investigating changes in the intracellular Ca(2+) concentration of different parasites and tissue culture cells during their interaction reveals the importance of [Ca(2+)](i) in the process of parasite-host cell interaction, as discussed here by Roberto Docampo and Silvia Moreno.
Journal ArticleDOI
Infection of mammalian cells with Theileria species.
TL;DR: The host range observed in this study corresponded to the known host range in vivo, and sporozoite attachment and infection was not observed with non-susceptible bovid host cells, nor were any of the non-bovid leucocytes infected by the parasites.