Journal ArticleDOI
The same but different: the biology of Theileria sporozoite entry into bovine cells
TLDR
It is suggested that the initial sporozoite binding event triggers the mobilization of intrasporozoite Ca2+ and the activation of both kinase and G-protein associated signalling processes in the parasite, which regulate the invasive capacity of the sporozoites.About:
This article is published in International Journal for Parasitology.The article was published on 1997-05-01. It has received 53 citations till now. The article focuses on the topics: Theileria & Theileria parva.read more
Citations
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Journal ArticleDOI
Theileria parva: sporozoite entry into bovine lymphocytes is not dependent on the parasite cytoskeleton.
TL;DR: The main conclusion from the present study is that T. parva sporozoite entry is dependent on a functional host cell actin cytoskeleton and is not driven by the parasite.
Journal ArticleDOI
Factors associated with seroconversion to the major piroplasm surface protein of the bovine haemoparasite Theileria orientalis
TL;DR: Temporal measurement of the serological response, parasite burden and packed cell volume in acutely infected animals revealed that seroconversion to the MPSP occurs within 2-3 weeks of the initial qPCR detection of the parasite and coincides with a peak in infection intensity and a declining PCV.
Journal ArticleDOI
Lymphocytes and Macrophages Are Infected by Theileria equi, but T Cells and B Cells Are Not Required to Establish Infection In Vivo
Joshua D. Ramsay,Massaro W. Ueti,Wendell C. Johnson,Glen A. Scoles,Donald P. Knowles,Donald P. Knowles,Robert H. Mealey +6 more
TL;DR: The findings suggest that the factors mediating Theileria equi leukocyte invasion and intracytoplasmic differentiation are common to several leukocytes subsets and are less restricted than for Theilia annulata and Theilaria parva.
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The invasion process of bovine erythrocyte by Babesia divergens: knowledge from an in vitro assay.
Yi Sun,Yi Sun,Emmanuelle Moreau,Emmanuelle Moreau,Alain Chauvin,Alain Chauvin,Laurence Malandrin +6 more
TL;DR: It is demonstrated that erythrocyte invasion by B. divergens is a rapid process since 70% of the invasion-competent parasites invaded the RBC in less than 45 s and despite a synchronous start, the parasite population evolved heterogeneously resulting in a progressive loss of synchronisation.
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Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton.
Jacqueline Schmuckli-Maurer,Jane Kinnaird,Sreerekha S. Pillai,Pascal Hermann,Sue McKellar,William Weir,Dirk A. E. Dobbelaere,Brian Shiels +7 more
TL;DR: Elevated levels of activated NF‐κB correlated with increased resistance to cell death and detection of parasite‐associated IKK signalosomes, supporting results of previous studies and providing evidence for the existence of host‐ and parasite‐dependent NF-κB activation pathways that are influenced by the architecture of the actin cytoskeleton.
References
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Models for the specific adhesion of cells to cells
TL;DR: The force required to separate two cells is shown to be greater than the expected electrical forces between cells, and of the same order of magnitude as the forces required to pull gangliosides and perhaps some integral membrane proteins out of the cell membrane.
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.
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Signal transduction by lymphocyte antigen receptors
Arthur Weiss,Dan R. Littman +1 more
TL;DR: Insight gained from studies of the signaling pathways downstream of TCR and BCR stimulation is likely to contribute significantly to future understanding of mechanisms responsible for lymphocyte differentiation and for the discrimination of self from nonself in developing and mature cells.
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Dimerization of cell surface receptors in signal transduction
TL;DR: This review focuses on the role of dimerization of cell surface receptors in signal transduction, which appears to be a mechanism of general applicability for the regulation of signalTransduction.