Journal ArticleDOI
The same but different: the biology of Theileria sporozoite entry into bovine cells
TLDR
It is suggested that the initial sporozoite binding event triggers the mobilization of intrasporozoite Ca2+ and the activation of both kinase and G-protein associated signalling processes in the parasite, which regulate the invasive capacity of the sporozoites.About:
This article is published in International Journal for Parasitology.The article was published on 1997-05-01. It has received 53 citations till now. The article focuses on the topics: Theileria & Theileria parva.read more
Citations
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Journal ArticleDOI
Cytoskeleton of Apicomplexan Parasites
TL;DR: The unusual properties of actin and myosin in the Apicomplexa, the highly stereotyped microtubule populations in apicOMplexans, and a network of recently discovered novel intermediate filament-like elements in these parasites are discussed.
Journal ArticleDOI
Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
TL;DR: Key parameters in T. parva population dynamics are the relative importance of asymptomatic carrier cattle and animals undergoing severe disease, in transmission of the parasite to ticks, and the extent of transmission by nymphs as compared to adult ticks.
Book ChapterDOI
Microneme Proteins in Apicomplexans
TL;DR: Structural and biochemical analyses of MIC domains is providing new perspectives on how adhesion is regulated and the potentially distinct roles MICs might play in long or short range interactions during parasite attachment and entry.
Journal ArticleDOI
Inhibition of apoptosis by intracellular protozoan parasites
TL;DR: Two families of molecules, which are known for their capacity to interrupt the apoptotic program, are currently discussed in the literature and can directly interfere with molecules of the cellular death machinery.
Journal ArticleDOI
Transformation of Leukocytes by Theileria parva and T. annulata
TL;DR: The presence of the parasite in the host-cell cytoplasm modulates the state of activation of a number of signal transduction pathways, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells.
References
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Journal ArticleDOI
The role of the cytoskeleton in the motility of coccidian sporozoites
D.G. Russell,R.E. Sinden +1 more
TL;DR: This proposed model for motility of coccidia sporozoites is consistent with all current observations on cell invasion by the sporozoa and therefore suggests that locomotion is an integral component of host cell invasion in this group of parasites.
Journal ArticleDOI
Rhoptry organelles of the apicomplexa: Their role in host cell invasion and intracellular survival.
TL;DR: The unifying and variant molecular features of rhoptry proteins are examined, and the role of multigene families in organelle function is addressed: the biogenesis of the rhoptries will be examined, in an attempt to understand the sequence of events leading to successful packaging, modification and processing of proteins within the organelle.
Journal ArticleDOI
Ca2+-dependence of conoid extrusion in Toxoplasma gondii tachyzoites
TL;DR: The results suggest that Ca2+‐release from internal stores may act as a key signal to activate a mechanism of conoid extrusion probably mediated, at least in part, by actin‐filaments.
Journal ArticleDOI
Bacterial entry into epithelial cells: the paradigm of Shigella
TL;DR: Shigella flexneri is a model for the entry of bacterial pathogens into nonphagocytic epithelial cells and triggers a reorganization of the host-cell cytoskeleton leading to the formation of membrane ruffles, which engulf the bacterium.
Journal ArticleDOI
Cell motility of sporozoan protozoa.
TL;DR: Conrad King discusses cellular motility particularly in sporozoites of Eimeria and Plasmodium, discussing current ideas about the possible motor mechanisms involved.