The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer.
Hazel R. Scott,Donald C. McMillan,L M Forrest,Duncan J.F Brown,Colin S. McArdle,Robert Milroy +5 more
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The results indicate that the majority of patients with inoperable non-small cell lung cancer have evidence of a systemic inflammatory response and an increase in the magnitude of the systemicinflammatory response resulted in greater weight loss, poorer performance status, more fatigue and poorer survival.Abstract:
The relationship between the magnitude of systemic inflammatory response and the nutritional/functional parameters in patients with inoperable non-small cell lung cancer were studied The extent of weight loss, albumin, C-reactive protein, performance status and quality of life was measured in 106 patients with inoperable non-small cell lung cancer (stages III and IV) Survival analysis was performed using the Cox proportional hazard model The majority of patients were male and almost 80% had elevated circulating C-reactive protein concentrations (>10 mg x l(-1)) On multivariate analysis, age (P=0012), tumour type (0002), weight loss (P=0056), C-reactive protein (P=0047), Karnofsky performance status (P=0002) and fatigue (P=0046) were independent predictors of survival The patients were grouped according to the magnitude of the C-reactive protein concentrations ( 100 mg x l(-1)) An increase in the magnitude of the systemic inflammatory response was associated with increased weight loss (P=0004), reduced albumin concentrations (P=0001), reduced performance status (P=0060), increased fatigue (P=0011) and reduced survival (HR 1936 95%CI 1414-2650, P<0001) These results indicate that the majority of patients with inoperable non-small cell lung cancer have evidence of a systemic inflammatory response Furthermore, an increase in the magnitude of the systemic inflammatory response resulted in greater weight loss, poorer performance status, more fatigue and poorer survivalread more
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References
More filters
Journal ArticleDOI
The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
Neil K. Aaronson,Sam H Ahmedzai,Bengt Bergman,Monika Bullinger,Ann Cull,Nicole Duez,Antonio Filiberti,Henning Flechtner,Stewart B. Fleishman,Johanna C. J. M. de Haes,Stein Kaasa,M. Klee,David Osoba,Darius Razavi,Peter B. Rofe,Simon Schraub,Kommer C. A. Sneeuw,Marianne Sullivan,Fumikazu Takeda +18 more
TL;DR: The reliability and validity of the EORTC QLQ-C30 questionnaire were highly consistent across the three language-cultural groups studied: patients from English-speaking countries, Northern Europe, and Southern Europe.
Journal ArticleDOI
A new international staging system for lung cancer
TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
Journal ArticleDOI
The Karnofsky Performance Status Scale. An examination of its reliability and validity in a research setting.
TL;DR: The utility of the Karnofsky Performance Status Scale as a valuable research tool when employed by trained observers is suggested and the relationship of the KPS to longevity in a population of terminal cancer patients documents its predictive validity.
Journal ArticleDOI
The new International Staging System for Lung Cancer.
TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
Journal ArticleDOI
Acute-phase protein response and survival duration of patients with pancreatic cancer.
J. S. Falconer,Kenneth C. H. Fearon,James A. Ross,R. Elton,Stephen J. Wigmore,O. J. Garden,David Carter +6 more
TL;DR: Whether certain nutritional indices and the acute‐phase protein response are prognostic factors independent of disease stage for patients with unresectable pancreatic cancer are determined.
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