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The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer.

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TLDR
The results indicate that the majority of patients with inoperable non-small cell lung cancer have evidence of a systemic inflammatory response and an increase in the magnitude of the systemicinflammatory response resulted in greater weight loss, poorer performance status, more fatigue and poorer survival.
Abstract
The relationship between the magnitude of systemic inflammatory response and the nutritional/functional parameters in patients with inoperable non-small cell lung cancer were studied The extent of weight loss, albumin, C-reactive protein, performance status and quality of life was measured in 106 patients with inoperable non-small cell lung cancer (stages III and IV) Survival analysis was performed using the Cox proportional hazard model The majority of patients were male and almost 80% had elevated circulating C-reactive protein concentrations (>10 mg x l(-1)) On multivariate analysis, age (P=0012), tumour type (0002), weight loss (P=0056), C-reactive protein (P=0047), Karnofsky performance status (P=0002) and fatigue (P=0046) were independent predictors of survival The patients were grouped according to the magnitude of the C-reactive protein concentrations ( 100 mg x l(-1)) An increase in the magnitude of the systemic inflammatory response was associated with increased weight loss (P=0004), reduced albumin concentrations (P=0001), reduced performance status (P=0060), increased fatigue (P=0011) and reduced survival (HR 1936 95%CI 1414-2650, P<0001) These results indicate that the majority of patients with inoperable non-small cell lung cancer have evidence of a systemic inflammatory response Furthermore, an increase in the magnitude of the systemic inflammatory response resulted in greater weight loss, poorer performance status, more fatigue and poorer survival

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References
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Journal ArticleDOI

A new international staging system for lung cancer

TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
Journal ArticleDOI

The Karnofsky Performance Status Scale. An examination of its reliability and validity in a research setting.

TL;DR: The utility of the Karnofsky Performance Status Scale as a valuable research tool when employed by trained observers is suggested and the relationship of the KPS to longevity in a population of terminal cancer patients documents its predictive validity.
Journal ArticleDOI

The new International Staging System for Lung Cancer.

TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
Journal ArticleDOI

Acute-phase protein response and survival duration of patients with pancreatic cancer.

TL;DR: Whether certain nutritional indices and the acute‐phase protein response are prognostic factors independent of disease stage for patients with unresectable pancreatic cancer are determined.
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