Journal ArticleDOI
The tandem of free radicals and methylglyoxal.
TLDR
It is arrived at that a tight junction exists between methylglyoxal toxicity and free radical (particularly ROS) generation, though the toxicity of 1,2-dicarbonyl evolves even under anaerobic conditions, too.About:
This article is published in Chemico-Biological Interactions.The article was published on 2008-02-15. It has received 220 citations till now. The article focuses on the topics: Methylglyoxal & Free Radical Formation.read more
Citations
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Journal ArticleDOI
Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation
TL;DR: The aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.
Journal ArticleDOI
Methylglyoxal, the dark side of glycolysis
TL;DR: A main emerging concept is that these two neural cell types have different and energetically adapted glyoxalase defense mechanisms which may serve as protective mechanism against methylglyoxal-induced cellular damage.
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Hyperglycemia and glycation in diabetic complications.
TL;DR: The mechanism of glycation and of AGEs formation and the role of hyperglycemia, A GEs, and oxidative stress in the pathophysiology of diabetic complications are summarized.
Journal ArticleDOI
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Kevin Pethe,Patricia C. Sequeira,Sanjay Agarwalla,Kyu Y. Rhee,Kelli Kuhen,Wai Yee Phong,Viral Patel,David Beer,John R. Walker,Jeyaraj Duraiswamy,Jan Jiricek,Thomas H. Keller,Arnab K. Chatterjee,Mai Ping Tan,Mai Ping Tan,Manjunatha Ujjini,Srinivasa P. S. Rao,Luis R. Camacho,Pablo Bifani,Puiying A. Mak,Ida Ma,S. Whitney Barnes,Zhong Chen,David Plouffe,Pamela Thayalan,Seow Hwee Ng,Melvin Au,Boon Heng Lee,Bee Huat Tan,Sindhu Ravindran,Mahesh Nanjundappa,Xiuhua Lin,Anne Goh,Suresh B. Lakshminarayana,Carolyn Shoen,Michael H. Cynamon,Barry N. Kreiswirth,Véronique Dartois,Eric C. Peters,Richard Glynne,Sydney Brenner,Thomas Dick +41 more
TL;DR: It is shown that inappropriate carbon-source selection can lead to the identification of compounds devoid of efficacy in vivo, underlining the importance of developing predictive in vitro screens and the need for understanding central bacterial metabolism in vivo.
Journal ArticleDOI
Two Major Medicinal Honeys Have Different Mechanisms of Bactericidal Activity
Paulus H. S. Kwakman,Anje A. te Velde,Leonie de Boer,Christina M. J. E. Vandenbroucke-Grauls,Sebastian A. J. Zaat +4 more
TL;DR: Honey is increasingly valued for its antibacterial activity, but knowledge regarding the mechanism of action is still incomplete, resulting in large differences in bactericidal activity of RS and manuka honey.
References
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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The measurement and mechanism of lipid peroxidation in biological systems.
TL;DR: Currently available assays for measuring peroxidation are reviewed--the more specific the assay used, the less peroxide is found in healthy human tissues and body fluids.
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Protein glycation and oxidative stress in diabetes mellitus and ageing
TL;DR: Overall, studies of glycation and protein browning suggest a critical role for oxidative processes perhaps involving decompartmentalized transition metals and a variety of low molecular weight reducing agents in diabetes mellitus and ageing.
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The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
TL;DR: Investigation has brought new developments in the involvement of the glyoxalase in cell growth and vesicle mobilization, with increasing evidence of changes in the gly oxalase system during tumor growth and diabete mellitus, particularly relating to the development of associated clinical complications.