Journal ArticleDOI
The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster.
Réka Albert,Hans G. Othmer +1 more
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TLDR
A Boolean model of the segment polarity gene network is proposed which is able to reproduce the wild-type gene expression patterns, as well as the ectopic expression patterns observed in overexpression experiments and various mutants, and gives important insights into the functioning of the network.About:
This article is published in Journal of Theoretical Biology.The article was published on 2003-07-07. It has received 900 citations till now. The article focuses on the topics: Gene regulatory network & Segment polarity gene.read more
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Network biology: understanding the cell's functional organization
TL;DR: This work states that rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize the view of biology and disease pathologies in the twenty-first century.
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Scale-free networks in cell biology
TL;DR: In this paper, the authors describe cellular network structure with graph concepts and reveal organizational features shared with numerous non-biological networks, such as the degree of interconnectivity and the complex control of cellular networks.
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The yeast cell-cycle network is robustly designed.
TL;DR: The cell-cycle regulatory network of the budding yeast is demonstrated to be extremely stable and robust for its function, and the results suggest that cellular regulatory networks are robustly designed for their functions.
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Robustness of cellular functions
TL;DR: This work states that theoretical approaches to complex engineered systems can provide guidelines for investigating cellular robustness and may be a key to understanding cellular complexity, elucidating design principles, and fostering closer interactions between experimentation and theory.
Journal ArticleDOI
Highly conserved non-coding sequences are associated with vertebrate development.
Adam Woolfe,Martin Goodson,Debbie K. Goode,Phil Snell,Gayle K. McEwen,Tanya Vavouri,Sarah Smith,Phil North,Heather Callaway,Krys Kelly,Klaudia Walter,Irina I. Abnizova,Walter R. Gilks,Yvonne J. K. Edwards,Julie E. Cooke,Greg Elgar +15 more
TL;DR: A whole-genome comparison between humans and the pufferfish, Fugu rubripes, is used to identify nearly 1,400 highly conserved non-coding sequences, which are likely to form part of the genomic circuitry that uniquely defines vertebrate development.
References
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Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
Hedgehog signaling in animal development: paradigms and principles.
TL;DR: In their screen for mutations that disrupt the Drosophila larval body plan, these authors identified several that cause the duplication of denticles and an accompanying loss of naked cuticle, characteristic of the posterior half of each segment.
Journal ArticleDOI
Wnt signaling: a common theme in animal development
Ken M. Cadigan,Roel Nusse +1 more
TL;DR: Current understanding of Wnt function and signaling mechanisms is reviewed in a comparative approach, highlighting novelty and underscoring questions that remain, and putting emphasis on the latest findings.
Book
The Embryonic Development of Drosophila melanogaster
TL;DR: Stages of Drosophila Embryogenesis, some Aspects of Segmentation, and a Fate Map of the Blastoderm are described.