Journal ArticleDOI
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals.
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TLDR
It is shown that the yeast S. cerevisiae has a remarkably similar UV response involving the AP-1 factor Gcn4, which is distinct from the DNA damage response, suggesting an ancient and universal mechanism involved in protection against damage to cellular components other than DNA.About:
This article is published in Cell.The article was published on 1994-05-06. It has received 223 citations till now. The article focuses on the topics: Ras Signaling Pathway & DNA damage.read more
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Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
TL;DR: This work investigated how TNFR1 activates different effector functions; the protein kinase JNK, transcription factor NF-kappaB, and apoptosis, finding that the three responses are mediated through separate pathways.
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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
Xiang Jiao Yang,Vasily Ogryzko,Jun-ichi Nishikawa,Jun-ichi Nishikawa,Bruce H. Howard,Yoshihiro Nakatani +5 more
TL;DR: A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A, a new adenoviral oncoprotein that induces progression through the cell cycle by binding to the products of the p300 and retinoblastoma gene families.
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Translational regulation of GCN4 and the general amino acid control of yeast.
TL;DR: M mammalian cells use the same strategy to downregulate protein synthesis while inducing transcriptional activators of stress-response genes under various stressful conditions, including amino acid starvation.
Journal ArticleDOI
Oxidative stress responses of the yeast Saccharomyces cerevisiae.
TL;DR: This review concentrates on the oxidant defence systems of the budding yeast Saccharomyces cerevisiae, which appears to have a number of inducible adaptive stress responses to oxidants, such as H2 O2 , superoxide anion and lipid peroxidation products.
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Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast
Krishnamurthy Natarajan,Michael R. Meyer,Belinda M. Jackson,David J. Slade,Christopher J. Roberts,Alan G. Hinnebusch,Matthew J. Marton +6 more
TL;DR: The broad transcriptional response evoked by Gcn4p is produced by diverse stress conditions, and numerous genes encoding protein kinases and transcription factors were identified as targets, suggesting that Gcn 4p is a master regulator of gene expression.
References
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Journal Article
ras Oncogenes in Human Cancer: A Review
TL;DR: It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly and some evidence that environmental agents may be involved in the induction of the mutations.
Book
DNA Repair and Mutagenesis
TL;DR: Nucleotide excision repair in mammalian cells: genes and proteins Mismatch repair The SOS response and recombinational repair in prokaryotes Mutagenesis in proKaryote Mutagenisation in eukaryotes Other DNA damage tolerance responses in eUKaryotes.
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The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
TL;DR: This work has identified a serine/threonine kinase whose activity is stimulated by the same signals that stimulate the amino-terminal phosphorylation of c-Jun, and suggests a mechanism through which protein kinase cascades can specifically modulate the activity of distinct nuclear targets.
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The SOS regulatory system of Escherichia coli
John W. Little,David W. Mount +1 more