Journal ArticleDOI
Three-dimensional echocardiographic ventricular mass/end-diastolic volume ratio in native hypertensive patients: relation between stroke volume and geometry.
Maria Lembo,Roberta Esposito,Ciro Santoro,Francesco Lo Iudice,Vincenzo Schiano-Lomoriello,Valeria Fazio,Maria Gabriella Grimaldi,Bruno Trimarco,Giovanni de Simone,Maurizio Galderisi +9 more
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3D-echo-derived LVM/EDV ratio identifies a higher prevalence of LV concentric geometry than 2D-relative wall thickness in native hypertensive patients, possibly detecting early myocardial damage in native-hypertensive patients.Abstract:
BACKGROUND Elevated left ventricular (LV) mass/end-diastolic volume ratio (LVM/EDV) has been associated with higher evidence of myocardial fibrosis and dysfunction in hypertensive patients by cardiac magnetic resonance, a technique with limited availability. OBJECTIVES We investigated the ability of three-dimensional (3D) echocardiography in identifying a phenotype of LV concentric geometry according to LVM/EDV ratio, possibly detecting early myocardial damage in native-hypertensive patients. METHODS One hundred and twenty-eight native-hypertensive patients underwent 2D and 3D-echocardiography. The population was divided into two groups, according to cut-off point values of 3D-LVM/EDV ratio corresponding to its upper 95% confidence interval in a population of 90 healthy normotensive individuals: LVM/EDV ratio cut-off was 1.22 in men and 1.23 in women. RESULTS An increased 3D-LVM/EDV ratio identified a higher rate of LV concentric geometry in comparison with 2D-derived relative wall thickness (37 versus 24%, P = 0.03). Patients with LVM/EDV ratio of 1.22 or more in men and 1.23 or more in women were significantly older, had smaller 3D-LV end-diastolic and end-systolic volumes and higher LV mass index, without difference in ejection fraction. 3D-stroke volume (P < 0.0001) was lower in patients with elevated LVM/EDV ratio. By a multilinear regression analysis, after adjusting for sex, age, heart rate, mean blood pressure and BMI, stroke volume was independently and negatively associated to LVM/EDV ratio (β = -0.55, P < 0.0001). CONCLUSION In native hypertensive patients, 3D-echo-derived LVM/EDV ratio identifies a higher prevalence of LV concentric geometry than 2D-relative wall thickness. Stroke volume is independently and negatively associated with LVM/EDV ratio and its reduction represents an early marker of myocardial dysfunction in hypertensives with LV concentric geometry.read more
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Journal ArticleDOI
Echocardiography in Arterial Hypertension
TL;DR: Detailed descriptions of the parameters that can be derived from a standard transthoracic echocardiogram are provided, including some more recent techniques.
Journal ArticleDOI
Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment.
Matteo Cameli,Maria Lembo,Carlotta Sciaccaluga,Francesco Bandera,Marco Matteo Ciccone,Antonello D'Andrea,Flavio D'Ascenzi,Roberta Esposito,Vincenzo Evola,Riccardo Liga,Giulia Elena Mandoli,Pasquale Palmiero,Ciro Santoro,Pietro Scicchitano,Regina Sorrentino,Annapaola Zito,Roberto Pedrinelli,Sergio Mondillo,Anna Vittoria Mattioli,Maurizio Galderisi +19 more
TL;DR: The present review highlights the advantage of additional echocardiographic parameters such as diastolic measurement and both thoracic and abdominal aortic dimensions, and suggests an overlook on aortIC valve should also be suggested to detect aorti regurgitation and stenosis in hypertensive patients.
Journal ArticleDOI
Low mechano‐energetic efficiency is associated with future left ventricular systolic dysfunction in hypertensives
Maria Virginia Manzi,Costantino Mancusi,Maria Lembo,Giovanni Esposito,Maria A.E. Rao,Giovanni de Simone,Carmine Morisco,Valentina Trimarco,Raffaele Izzo,Bruno Trimarco +9 more
TL;DR: In hypertensive setting, MEEi evaluation improves risk stratification for development of LV systolic dysfunction during long-term follow-up and is independently associated with the evolution towards LVEF reduction.
Journal ArticleDOI
Interrelation between midwall mechanics and longitudinal strain in newly diagnosed and never-treated hypertensive patients without clinically defined hypertrophy.
Maria Lembo,Ciro Santoro,Regina Sorrentino,Mario Enrico Canonico,Valeria Fazio,Bruno Trimarco,Marijana Tadic,Maurizio Galderisi,Roberta Esposito +8 more
TL;DR: In newly diagnosed and never-treated hypertensive patients without LVH, an early LV systolic dysfunction is testified by the reduction of both MFS and GLS, which resulted independently associated after adjusting for several confounders.
Journal ArticleDOI
Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances
Valentina Trimarco,Maria Virginia Manzi,Costantino Mancusi,Teresa Strisciuglio,Ilaria Fucile,Antonella Fiordelisi,Emanuele Pilato,Raffaele Izzo,Emanuele Barbato,Maria Lembo,Carmine Morisco +10 more
TL;DR: It is shown that improving insulin resistance condition is a necessary step to ameliorate vitamin D supplementation-based strategies in cardiovascular prevention, and indicates that improving the cardiovascular risk profile and prognosis of patients with cardiovascular diseases is not sufficient.
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TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.