Thrombocytopenia and its association with mortality in patients with COVID-19.
TLDR
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes novel coronav virus disease 2019 (COVID‐19), is spreading rapidly around the world.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2020-06-01 and is currently open access. It has received 355 citations till now.read more
Citations
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Platelet gene expression and function in patients with COVID-19.
Bhanu Kanth Manne,Frederik Denorme,Elizabeth A. Middleton,Irina Portier,Jesse W. Rowley,Chris Stubben,Aaron C. Petrey,Neal D. Tolley,Li Guo,Mark J. Cody,Andrew S. Weyrich,Christian C. Yost,Matthew T. Rondina,Robert A. Campbell +13 more
TL;DR: It is demonstrated that SARS-CoV-2 infection is associated with platelet hyperreactivity, which may contribute to COVID-19 pathophysiology.
Journal ArticleDOI
Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19.
Eugenio D. Hottz,Eugenio D. Hottz,Isaclaudia G. de Azevedo-Quintanilha,Lohanna Palhinha,Lívia Teixeira,Ester A. Barreto,Camila R. R. Pão,Cassia Righy,Sérgio Franco,Thiago Moreno L. Souza,Pedro Kurtz,Fernando A. Bozza,Patrícia T. Bozza +12 more
TL;DR: It is demonstrated that increased platelet activation and platelet-monocyte aggregate formation are observed in severe COVID-19 patients, but not in patients presenting mild CO VID-19 syndrome, and these data shed light on new pathological mechanisms involving plateletactivation and Platelet-dependent monocyte TF expression, which were associated with COVID -19 severity and mortality.
Journal ArticleDOI
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Si Zhang,Yangyang Liu,Xiaofang Wang,Li Yang,Haishan Li,Yuyan Wang,Mengduan Liu,Xiaoyan Zhao,Youhua Xie,Yan Yang,Shenghui Zhang,Zhichao Fan,Jianzeng Dong,Zhenghong Yuan,Zhongren Ding,Yi Zhang,Liang Hu +16 more
TL;DR: A novel function of SARS-CoV-2 on platelet activation via binding of Spike to ACE2 is uncovered, which may participate in thrombus formation and inflammatory responses in COVID-19 patients.
Journal ArticleDOI
The role of biomarkers in diagnosis of COVID-19 - A systematic review.
TL;DR: In this article, a systematic review of the literature was carried out to identify relevant articles using six different databases, including COVID-19, SARS-CoV2, and Biomarkers.
Journal ArticleDOI
Prognostic Factors for Severity and Mortality in Patients Infected with COVID-19: A Systematic Review
Ariel Izcovich,Martín Ragusa,Fernando Tortosa,María Andrea Lavena Marzio,Camila Agnoletti,Agustín Bengolea,Agustina Ceirano,Federico Espinosa,Ezequiel Alvarez Saavedra,Verónica Sanguine,Alfredo Tassara,Candelaria Cid,Hugo N Catalano,Arnav Agarwal,Farid Foroutan,Gabriel Rada +15 more
TL;DR: In this article, a systematic review is conducted to identify prognostic factors that may be used in decision-making related to the care of patients infected with SARS-CoV-2.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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