Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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Dissertation
Use of organ-culture, irradiation and adoptive-transfer to investigate the role of the Xenopus thymus in T lymphocyte development
TL;DR: This Thesis attempts to develop an amphibian model system for exploring the role of the thymus, particularly its stromal cells, in the acquisition of allotolerance and investigates in vitro T-cell proliferative responses of splenocytes and thymocytes in allothymus-implanted, early- thymectomized Xenopus.
Journal ArticleDOI
In vitro stimulation of rabbit T lymphocytes by cells expressing herpes simplex antigens
TL;DR: T lymphocytes from rabbits immunized with herpes simplex virus were specifically activated by herpesvirus-infected X-irradiated cells; lymph node cells from rabbits Immunized with RK13 cells and from non-immune rabbits showed no proliferative response.
Journal ArticleDOI
Virus-specific proliferative T-cell responses: Parameters and specificity
G. Kreeb,R.M. Zinkernagel +1 more
TL;DR: Under these conditions, T cells proliferated in the tertiary response to virus-specific stimulation, whereas background proliferation caused by allogeneic differences between stimulator and responder cells was minimal.
Book ChapterDOI
Thymic Influences on T Cell Development
TL;DR: Results obtained support the notion that cells entering the thymic rudiment are not already committed to a particular T cell lineage but undergo diversification within theThymus, and the progeny of a single precursor recolonizing an alymphoid thymus can give rise to multiple T cell receptor β-chain gene rearrangements, providing direct evidence for intrathymic diversification of the receptor repertoire.
Book ChapterDOI
Adaptive Immunity and the Tumor Microenvironment
TL;DR: Effective immunotherapies are still limited, given the complexities of this highly evolved and selected tumor microenvironment, and Cytokine therapies and Immune Checkpoint Blockade enable immune effector function and are largely dependent on the shape and size of the B and T cell repertoires (the "adaptome").
References
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Journal ArticleDOI
Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
Journal ArticleDOI
Histocompatibility-Linked Immune Response Genes
TL;DR: The chapter presents a description of the specific immune responses that are under the control of H-linked Ir genes in guinea pigs, mice, and rats.
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
Journal ArticleDOI
The influence of immunologically committed lymphoid cells on macrophage activity in vivo
TL;DR: It has been shown that the immune response of mice to infection with L. monocytogenes gives rise to a population of immunologically committed lymphoid cells which have the capacity to confer protection and a proportionate level of delayed-type hypersensitivity upon normal recipients.
Journal ArticleDOI
The somatic generation of immune recognition.
TL;DR: The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs.