Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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Sequential analysis of the thymocyte differentiation in fully allogeneic bone marrow chimera in mice. I. Relationship between functions and surface characteristics of thymocytes.
Kazumasa Ogasawara,Noriko Fukushi,Hisashi Arase,Chikako Iwabuchi,Shigetsugu Hatakeyama,Kazuya Iwabuchi,Robert A. Good,Kazunori Onoá +7 more
TL;DR: The findings demonstrated that the process of thymocyte differentiation in the fully allogeneic chimeras was similar to ontogenic development as observed in fetal mice, however, the tempo at which the differentiation of surface phenotypes and development of functions proceeded was quite different from that seen in normal mice.
Journal ArticleDOI
Interaction between thymocytes and thymus-derived macrophages. II. Engulfment of thymocytes by macrophages.
Michael Zeira,Ruth Gallily +1 more
TL;DR: It is concluded that cell to cell contact is necessary for thymocyte elimination and that bone marrow-derived macrophages internalized immature thymocytes to a degree similar to TDM phi.
Journal ArticleDOI
In situ characterization in freeze-fractured mouse thymuses of lymphoepithelial complexes ultrastructurally similar to isolated thymic nurse cells.
TL;DR: Scanning and transmission electron microscopy of the cracked surfaces of cryofractured pre-fixed C57BL/Ka mouse thymus reveals the existence of cell complexes, distinct from the surrounding cell organization, in which groups of lymphocytes are delimited by large cytoplasmic sheets or envelopes.
Journal ArticleDOI
Negative selection experiments support the idea that T-T help is required for the H-Y-specific cytotoxic T cell response☆
TL;DR: The results support the idea that concurrent presence of helper T cells specific for H-Y-H-2-I-A b is required for the generation of secondary cytotoxic T lymphocyte responses to H-D-2D b.
References
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Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
Journal ArticleDOI
Histocompatibility-Linked Immune Response Genes
TL;DR: The chapter presents a description of the specific immune responses that are under the control of H-linked Ir genes in guinea pigs, mice, and rats.
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
Journal ArticleDOI
The influence of immunologically committed lymphoid cells on macrophage activity in vivo
TL;DR: It has been shown that the immune response of mice to infection with L. monocytogenes gives rise to a population of immunologically committed lymphoid cells which have the capacity to confer protection and a proportionate level of delayed-type hypersensitivity upon normal recipients.
Journal ArticleDOI
The somatic generation of immune recognition.
TL;DR: The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs.