Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
TL;DR: These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype and it is possible to study biological function as well as antigen specificity using T cell lines.
Book
The house mouse
TL;DR: The house mouse is a small, slender rodent that has a slightly pointed nose; small, black, somewhat protruding eyes; large, scantily haired ears, and a nearly hairless tail with obvious scale rings.
Journal ArticleDOI
Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice.
TL;DR: Intathymic injection of fluorescein isothiocyanate is used to label thymocytes in situ and so can be used to quantitate the extent of migration of cells from the thymus to the periphery.
Journal Article
In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells
TL;DR: The authors showed that host H-2 antigens do exert an effect on the specificity of T-cell responses, and that CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H 2 in addition to self H 2.
References
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Journal Article
The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism.
Journal ArticleDOI
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.
TL;DR: It is concluded that the chimaeric host determines the specificity of T cell restriction either through a thymic selection process as proposed by Jerne or alternatively through an antigen presentation mechanism.
Book ChapterDOI
H-2 mutations: their genetics and effect on immune functions.
TL;DR: Methods of detection and analysis of histocompatibility mutations in general and H-2 mutations in particular are described and data is presented on the way mutations change these functions.
Journal ArticleDOI
Studies on artificial antigens : iii. the genetic control of the immune response to hapten-poly-l-lysine conjugates in guinea pigs
TL;DR: Findings in guinea pigs are consistent with the view that the capacity to respond immunologically to hapten-polylysine conjugates is genetically transmitted as a unigenic Mendelian dominant.
Book ChapterDOI
The role of products of the histocompatibility gene complex in immune responses
TL;DR: The authors showed that gene differences in the I region of the H-2 complex prevent the development of T-B cell interactions irrespective of the existence of gene identities elsewhere in the H2 complex (including the I-C subregion).