Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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Vaccines and the future of human immunology
TL;DR: This Perspective is designed to provide a broad overview that discusses the present limitations in designing effective novel vaccines for diseases that do not typically induce robust resistance in infected individuals and how the addition of a systems-level, multiplexed approach to the analysis of the human immune system can complement traditional highly focused research efforts to accelerate progress toward this goal and the improvement of human health.
Journal ArticleDOI
Dominance of one T-cell receptor in the H-2Kb/TNP response.
Ute Hochgeschwender,Hans Georg Simon,Hans Ulrich Weltzien,Frauke Bartels,Andrea Becker,Jörg T. Epplen +5 more
TL;DR: It is shown that a strong selective pressure acted on the Tc population, resulting in a skewing of the TCR repertoire for H–2Kb/TNP and in the dominant expression of one TCR with this specificity.
Journal ArticleDOI
Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti-idiotypic antibodies in rabbits.
Margaret Winkler,Jean-Denis Franssen,Catherine Collignon,Oberdan Leo,B Mariamé,P van de Walle,Donat De Groote,Jacques Urbain +7 more
TL;DR: It seems that Ab3 looks idiotypically like Ab1 and Ab4 displays the same behaviour as Ab2, and a general view of the functioning of the immune system is presented.
Journal ArticleDOI
Fine specificity of alloimmune cytotoxic T lymphocytes directed against H-2K. A study with Kb mutants.
TL;DR: Comparison with other reports supports the notion that the system of Kb CML determinants, recognized by alloimmune CTL, is at least partially overlapping with the H-2Kb specificity repertoire involved in the associative T cell recognition of virus-infected cells.
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Extracellular matrix of the human thymus: immunofluorescence studies on frozen sections and cultured epithelial cells.
S Berrih,Wilson Savino,S Cohen +2 more
TL;DR: Results show thatThymic epithelial cells participate in the synthesis of extracellular matrix elements, which as a result of their localization and influence on epithelial cell growth, should be regarded as constitutive components of the thymic microenvironment.
References
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Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
Journal ArticleDOI
Histocompatibility-Linked Immune Response Genes
TL;DR: The chapter presents a description of the specific immune responses that are under the control of H-linked Ir genes in guinea pigs, mice, and rats.
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
Journal ArticleDOI
The influence of immunologically committed lymphoid cells on macrophage activity in vivo
TL;DR: It has been shown that the immune response of mice to infection with L. monocytogenes gives rise to a population of immunologically committed lymphoid cells which have the capacity to confer protection and a proportionate level of delayed-type hypersensitivity upon normal recipients.
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The somatic generation of immune recognition.
TL;DR: The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs.