Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.
TL;DR: An in vitro T lymphocyte-dependent B lymphocyte proliferation assay is developed and finds that the apparent lack of antigen specificity in the face of Ir gene-restricted T-B interaction may have important implications in the understanding of the recognition unit(s) on T lymphocytes.
Journal ArticleDOI
Cytotoxic T lymphocyte recognition of HLA-A2 antigens in normal and HLA-Cw3-transgenic mice.
TL;DR: It is well established that a large fraction of murine cytotoxic T cells can recognize allogeneic major histocompatibility complex (MHC) antigens, and that the majority of this response are not restricted by H‐2 antigen of the responding host.
Journal ArticleDOI
Quantitative Variation in H-2-Antigen Expression I. Estimation of H-2K and H-2D Expression in Different Strains of Mice
TL;DR: The method involved the use of an125I-protein A radioimmunoassay using highly specific anti-H-2 sera to make estimates of the number of cell-bound antibody molecules to estimate the maximum number of antibody binding sites for each H-2 antigen.
Journal ArticleDOI
Clonal anergy in self-reactive α/β T cells is abrogated by heat-shock protein-reactive γ/δ T cells in aged athymic nude mice
Hiroyuki Yuuki,Yasunobu Yoshikai,Kenji Kishihara,Akinori Iwasaki,Goto Matsuzaki,Hiroaki Takimoto,Kikuo Nomoto +6 more
TL;DR: The results suggest that unresponsiveness of self‐reactive T cells may be reversed by T cells responding to stress proteins expressed by the invading microbes and/or the stressed autologous cells.
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Limited regions of the α2-domain α-helix control anti-A2 allorecognition: an analysis using a panel of A2 mutants
Giovanna Lombardi,Masanori Matsui,Robert J. Moots,Gerald Aichinger,Sid Sidhu,Richard Batchelor,Jeff Frelinger,Robert I. Lechler +7 more
TL;DR: The results suggest that the specificity of alloreactive T cells is determined by exposed polymorphisms, directly contacted by the Tcr, and by concealed polymorphisms which influence peptide binding.
References
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Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
Journal ArticleDOI
Histocompatibility-Linked Immune Response Genes
TL;DR: The chapter presents a description of the specific immune responses that are under the control of H-linked Ir genes in guinea pigs, mice, and rats.
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
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The influence of immunologically committed lymphoid cells on macrophage activity in vivo
TL;DR: It has been shown that the immune response of mice to infection with L. monocytogenes gives rise to a population of immunologically committed lymphoid cells which have the capacity to confer protection and a proportionate level of delayed-type hypersensitivity upon normal recipients.
Journal ArticleDOI
The somatic generation of immune recognition.
TL;DR: The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs.