Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
TL;DR: These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype and it is possible to study biological function as well as antigen specificity using T cell lines.
Book
The house mouse
TL;DR: The house mouse is a small, slender rodent that has a slightly pointed nose; small, black, somewhat protruding eyes; large, scantily haired ears, and a nearly hairless tail with obvious scale rings.
Journal ArticleDOI
Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice.
TL;DR: Intathymic injection of fluorescein isothiocyanate is used to label thymocytes in situ and so can be used to quantitate the extent of migration of cells from the thymus to the periphery.
Journal Article
In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells
TL;DR: The authors showed that host H-2 antigens do exert an effect on the specificity of T-cell responses, and that CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H 2 in addition to self H 2.
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Journal ArticleDOI
The specificity of thymus-derived T-cells in cell-mediated cytotoxic reactions.
TL;DR: Studies examining the specificity of T cell recognition in binding and functional assays indicate that the ability to discriminate between closely related but diJBEerent synthetic antigens is at least as great as that found with the B cell.
Journal ArticleDOI
Studies of the immunological capacity of germ-free mouse radiation chimeras: I. Chimerism and humoral immune response☆
TL;DR: The genetic origin of both the functional lymphoid cell and progenitor cell populations of allogeneic mouse radiation chimeras was assessed by indirect immunofluorescence (IIF), anti-H-2 cytotoxicity, and survival of lethally x-irradiated secondary recipients of chimera cell populations as discussed by the authors.
Journal ArticleDOI
Studies of the immunological capacity of germ-free mouse radiation chimeras: IV. Cell-mediated immunity
TL;DR: The helper cell and effector cell, both associated with T-derived lymphocytes, represent two different populations, and although allogeneic chimeras contain cells potentially reactive toward host antigens, cells cytotoxic to host antIGens were not detectable.
Journal ArticleDOI
Abnormal immune mechanism in allogeneic radiation chimeras.
TL;DR: The allogeneic chimeras showed almost normal amounts of serumn antibody after a third injection of antigen but a relative defect in their ability to synthesize antibody resistant to 2-mercaptoethanol.