Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
Citations
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Early events in T lymphocyte genesis in the fetal thymus.
TL;DR: Arguments are presented here which raise doubts about the claims that these cells have undergone substantial maturation along the T-lineage pathway prior to migration to the thymus, placing emphasis on the role of thymic stromal cells in T-lymphocyte maturation.
Journal ArticleDOI
An enzyme-linked immunosorbent assay (ELISA) for detergent solubilized Ia glycoproteins using nitrocellulose membrane discs.
TL;DR: An enzyme-linked immunosorbent assay has been developed for the quantitative detection of detergent solubilized murine Ia that could readily detect partially purified Ia derived from 10(3) to 10(4) mitogen stimulated spleen cells.
Journal ArticleDOI
TCR Signaling for Initiation and Completion of Thymocyte Positive Selection Has Distinct Requirements for Ligand Quality and Presenting Cell Type
TL;DR: The results argue that despite the negative role assigned to DC, neither the peptide:MHC molecule complexes present on DC nor any other signals provided by these cells stimulate only thymocyte death, and indicate that unique epithelial ligands are not necessary for positive selection.
Journal ArticleDOI
Immuno-histochemical characterisation of cells involved in dermatopathic lymphadenopathy
TL;DR: Normal and pathological lymph nodes exhibiting the features of dermatopathic lymphadenopathy were analysed by immunochemical methods and strong Ia expression seems to be restricted to a subclass of mesenchymal cells which might be involved in the regulation of T cell function.
Journal ArticleDOI
A quantitative theory of affinity-driven T cell repertoire selection.
TL;DR: The role of the MHC and peptide contribution to TCR binding is analysed, and it is found that their relative, rather than absolute value, is important in shaping the mature repertoire.
References
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Journal ArticleDOI
Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
Journal ArticleDOI
Histocompatibility-Linked Immune Response Genes
TL;DR: The chapter presents a description of the specific immune responses that are under the control of H-linked Ir genes in guinea pigs, mice, and rats.
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
Journal ArticleDOI
The influence of immunologically committed lymphoid cells on macrophage activity in vivo
TL;DR: It has been shown that the immune response of mice to infection with L. monocytogenes gives rise to a population of immunologically committed lymphoid cells which have the capacity to confer protection and a proportionate level of delayed-type hypersensitivity upon normal recipients.
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The somatic generation of immune recognition.
TL;DR: The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs.