Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
About:
This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
Citations
More filters
Book ChapterDOI
Thymic Nurse Cells: a Site for Positive Selection and Differentiation of T Cells
TL;DR: The most widely — albeit not exclusively — accepted hypothesis postulates that thymocytes expressing T cell receptors with affinity to MHC class I and II molecules displayed on cortical epithelial cells are positively selected (MHC restriction).
Journal ArticleDOI
Analysis of haplotype preference in the cytotoxic T-cell response to H-Y.
TL;DR: Investigation of the mechanism determining which parental haplotype is selected in F1 female mice for major histocompatibility complex restricted, male-specific, immune, cytotoxic T-cell responses found evidence for natural tolerance as a possible mechanism to explain haplotype preference.
Journal ArticleDOI
Interferon, nk cells and persistent virus infection*
TL;DR: The existence of persistent viral infections in man, and slow viral diseases thought to be caused by them, indicate that these two lines of defense are insufficient to prevent or eliminate persistent viral infection in at least some hosts, and immunological mechanisms effective against persistently infected cells remain unclear.
Journal ArticleDOI
A random repertoire of V genes for T-cell receptors? Theoretical implications of recent experimental observations on T-cell specificity and self-restriction.
TL;DR: Several theoretical implications of recent experimental observations on T-cell specificity and self-restriction are described, including the fact that helper T cells and cytotoxic T cells are mainly restricted to I-region and K- or D-region determinants implies that the selection for self-MHA restriction commits inherently the selected young T lineage cells to helper or cytot toxic function depending on the type of selecting MHA.
Journal ArticleDOI
Induction of autoanti-idiotypic antibodies and effects on the subsequent immune response.
TL;DR: It is shown that individual rabbits are able to synthesize antibodies directed against their own idiotypic determinants and such an induction of autoanti-idiotypic antibodies is shown to modulate the idiotypics expression when the animal is subsequently restimulated by the original antigen.
References
More filters
Journal ArticleDOI
Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
Journal ArticleDOI
Histocompatibility-Linked Immune Response Genes
TL;DR: The chapter presents a description of the specific immune responses that are under the control of H-linked Ir genes in guinea pigs, mice, and rats.
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
Journal ArticleDOI
The influence of immunologically committed lymphoid cells on macrophage activity in vivo
TL;DR: It has been shown that the immune response of mice to infection with L. monocytogenes gives rise to a population of immunologically committed lymphoid cells which have the capacity to confer protection and a proportionate level of delayed-type hypersensitivity upon normal recipients.
Journal ArticleDOI
The somatic generation of immune recognition.
TL;DR: The present hypothesis proposes that the germ‐cells of an animal carry a set of v‐genes determining the combining sites of antibodies directed against a complete set of a certain class of histocompatibility antigens of the species to which this animal belongs.