Journal ArticleDOI
Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H-2-Restriction-Specificity and in H-2 Linked Ir Gene Control
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This article is published in Immunological Reviews.The article was published on 1978-12-01. It has received 285 citations till now. The article focuses on the topics: T cell.read more
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Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
TL;DR: These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype and it is possible to study biological function as well as antigen specificity using T cell lines.
Book
The house mouse
TL;DR: The house mouse is a small, slender rodent that has a slightly pointed nose; small, black, somewhat protruding eyes; large, scantily haired ears, and a nearly hairless tail with obvious scale rings.
Journal ArticleDOI
Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice.
TL;DR: Intathymic injection of fluorescein isothiocyanate is used to label thymocytes in situ and so can be used to quantitate the extent of migration of cells from the thymus to the periphery.
Journal Article
In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells
TL;DR: The authors showed that host H-2 antigens do exert an effect on the specificity of T-cell responses, and that CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H 2 in addition to self H 2.
References
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Journal ArticleDOI
T cell function in bone marrow chimeras: absence of host-reactive T cells and cooperation of helper T cells across allogeneic barriers.
H von Boehmer,Jonathan Sprent +1 more
TL;DR: Recent observations on tolerance to several antigens, including histocompatibility markers (Droege 1975), suggest active suppression and thus challenge the concept of clona! deletion (Bumet & Fenner 1949, Lederberg 1959).
Journal ArticleDOI
In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells
TL;DR: The results indicate that in chimeras, the Ir phenotype is independent of the donor T cell’s Ir genotype, and that thymic selection of a T cell ’s restriction specificity for a particular H-2 allele of the chimeric host also defines that T cell's/r phenotype.
Journal ArticleDOI
Multiple H-2-linked immune response gene control of H-2D- associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region
Schmitt-Verhulst Am,Shearer Gm +1 more
TL;DR: Findings raise the possibility that multiple genes mapping within different regions of the MHC control the level of T-cell-mediated cytotoxicity to chemically modified autologous cells.
Journal ArticleDOI
Multiple Polymorphism in Relation to Histocompatibility Antigens
TL;DR: The extreme polymorphism of the histo-compatibility antigens may have evolved to ensure that the body of an individual is not invaded by cells from another individual of the same species.
Journal Article
Neonatal Tolerance Induction across Regions of H-2 Complex
J W Streilein,Jan Klein +1 more
TL;DR: The K region of the H-2 complex is not only highly immunogenic, but markedly resistant to neonatalolerance induction, especially apparent when the host is derived from B10 stocks, indicating that genetic factors unlinked to the MHC clearly play an important role in determining the ease of neonatal tolerance induction.