Journal ArticleDOI
TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway.
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TLDR
In this article , the authors identified TIGAR as a potential regulator of ferroptosis resistance in the development of colorectal cancer and showed that TIGar expression in CRC tissues is significantly higher than that in adjacent normal tissues.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2022-03-01. It has received 23 citations till now. The article focuses on the topics: Medicine & Gene knockdown.read more
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Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis
TL;DR: In this paper , it was shown that a knockdown of HULC increases ferroptosis and oxidative stress in liver cancer cells. But, it is unclear as to whether FerroPTosis is involved with the mechanisms of lncRNA hULC in hepatocellular carcinoma.
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Targeting Ferroptosis in Colorectal Cancer
TL;DR: A comprehensive evaluation of the main mechanisms of iron metabolism, lipid metabolism, and amino acid metabolism involved in the occurrence of ferroptosis, as well as the research progress of ferraptosis in CRC is provided.
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Insights on Ferroptosis and Colorectal Cancer: Progress and Updates
TL;DR: A review of the current research progress on the mechanism of ferroptosis in colorectal cancer can be found in this paper , where several regulatory molecules and pathways have been identified.
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Mechanism and application of ferroptosis in colorectal cancer.
TL;DR: In this article , the authors reviewed the mechanism of ferroptosis and the possibility to target the pathway in colorectal cancer and provided new ideas for the diagnosis and treatment of CRC.
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DNA methylation of RUNX3 promotes the progression of gallbladder cancer through repressing SLC7A11-mediated ferroptosis.
Chen Cai,Yidi Zhu,Jiasheng Mu,Shilei Liu,Ziyi Yang,Zi-You Wu,Chengquan Zhao,Xiaoling Song,Yuanyuan Ye,Jun Gu,Xiang-Ru Wu,Wei Gong +11 more
TL;DR: Zhang et al. as discussed by the authors used bisulfate sequencing PCR (BSP), Western blot, and qPCR to identify the expression level and DNA methylation level of RUNX3 in gallbladder cancer (GBC) tissues and cells.
References
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Journal ArticleDOI
Cancer Statistics, 2021.
TL;DR: In the United States, the cancer death rate has dropped continuously from its peak in 1991 through 2018, for a total decline of 31%, because of reductions in smoking and improvements in early detection and treatment as mentioned in this paper.
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UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.
Darshan S. Chandrashekar,Bhuwan Bashel,Sai Akshaya Hodigere Balasubramanya,Chad J. Creighton,Israel Ponce-Rodriguez,Balabhadrapatruni V. S. K. Chakravarthi,Sooryanarayana Varambally +6 more
TL;DR: UALCAN, an easy to use, interactive web-portal to perform to in-depth analyses of TCGA gene expression data, serves as a platform for in silico validation of target genes and for identifying tumor sub-group specific candidate biomarkers.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
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TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
TL;DR: expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.
Journal ArticleDOI
Ferroptosis: mechanisms, biology and role in disease.
TL;DR: In this paper, the authors provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of the potential therapeutic roles, and its pathological roles, together with a potential for therapeutic targeting.