Journal ArticleDOI
Titanium-based nanomaterials for cancer theranostics
TLDR
The research of titanium-based nanomaterials (Ti-based NMs) has gradually expanded from the fields of photocatalysis, electronics, energy, and engineering to biomedicine in recent years.About:
This article is published in Coordination Chemistry Reviews.The article was published on 2021-03-01. It has received 59 citations till now.read more
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Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies.
Jianlei Xie,Yingwei Wang,Yingwei Wang,Won Seok Choi,Paramesh Jangili,Yanqi Ge,Yunjie Xu,Yunjie Xu,Jianlong Kang,Liping Liu,Bin Zhang,Zhongjian Xie,Jun He,Ni Xie,Guohui Nie,Han Zhang,Jong Seung Kim +16 more
Abstract: Photodynamic therapy (PDT) has been extensively investigated for decades for tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability. It can be a promising treatment modality in several medical fields, including oncology, immunology, urology, dermatology, ophthalmology, cardiology, pneumology, and dentistry. Nevertheless, the clinical application of PDT is largely restricted by the drawbacks of traditional photosensitizers, limited tissue penetrability of light, inefficient induction of tumor cell death, tumor resistance to the therapy, and the severe pain induced by the therapy. Recently, various photosensitizer formulations and therapy strategies have been developed to overcome these barriers. Significantly, the introduction of nanomaterials in PDT, as carriers or photosensitizers, may overcome the drawbacks of traditional photosensitizers. Based on this, nanocomposites excited by various light sources are applied in the PDT of deep-seated tumors. Modulation of cell death pathways with co-delivered reagents promotes PDT induced tumor cell death. Relief of tumor resistance to PDT with combined therapy strategies further promotes tumor inhibition. Also, the optimization of photosensitizer formulations and therapy procedures reduces pain in PDT. Here, a systematic summary of recent advances in the fabrication of photosensitizers and the design of therapy strategies to overcome barriers in PDT is presented. Several aspects important for the clinical application of PDT in cancer treatment are also discussed.
Journal ArticleDOI
Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances.
Chenyang Jia,Yuxin Guo,Fu-Gen Wu +2 more
TL;DR: In this article, the latest advancements in the nanomaterials-involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.
Journal ArticleDOI
ROS-based dynamic therapy synergy with modulating tumor cell-microenvironment mediated by inorganic nanomedicine
TL;DR: Various strategies to modulate tumor cell-microenvironment to enhance the efficacy of DT, by reliving hypoxia, augmenting hydrogen peroxide (H2O2), adjusting the pH, and depleting GSH are summarized.
Journal ArticleDOI
Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy
Panchanathan Manivasagan,Ara Joe,Hyo-Won Han,Thavasyappan Thambi,Manickam Selvaraj,Kumarappan Chidambaram,Jungbae Kim,Eue-Soon Jang +7 more
TL;DR: In this paper , the potential and challenges in the future development of photothermal-enhanced Fenton-based nanocatalytic tumor therapy for clinical application are discussed, and a comprehensive review on this subject is presented.
Journal ArticleDOI
A multimodal strategy of Fe3O4@ZIF-8/GOx@MnO2 hybrid nanozyme via TME modulation for tumor therapy
TL;DR: In this paper, a hybrid nano-zyme for tumor therapy was constructed, which can facilitate the transformation of M2-type macrophages to M1-type, and strong systemic antitumor immune effect was induced.
References
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Journal ArticleDOI
Cancer statistics, 2020.
TL;DR: Slow momentum for some cancers amenable to early detection is juxtaposed with notable gains for other common cancers, and it is notable that long‐term rapid increases in liver cancer mortality have attenuated in women and stabilized in men.
Journal ArticleDOI
Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
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Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
TL;DR: It is believed that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve the ability to combat cancers.
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Are MXenes Promising Anode Materials for Li Ion Batteries? Computational Studies on Electronic Properties and Li Storage Capability of Ti3C2 and Ti3C2X2 (X = F, OH) Monolayer
Qing Tang,Zhen Zhou,Panwen Shen +2 more
TL;DR: The exceptional properties, including good electronic conductivity, fast Li diffusion, low operating voltage, and high theoretical Li storage capacity, make Ti(3)C(2) MXene a promising anode material for Li ion batteries.