Journal ArticleDOI
Titanium-based nanomaterials for cancer theranostics
TLDR
The research of titanium-based nanomaterials (Ti-based NMs) has gradually expanded from the fields of photocatalysis, electronics, energy, and engineering to biomedicine in recent years.About:
This article is published in Coordination Chemistry Reviews.The article was published on 2021-03-01. It has received 59 citations till now.read more
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Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies.
Jianlei Xie,Yingwei Wang,Yingwei Wang,Won Seok Choi,Paramesh Jangili,Yanqi Ge,Yunjie Xu,Yunjie Xu,Jianlong Kang,Liping Liu,Bin Zhang,Zhongjian Xie,Jun He,Ni Xie,Guohui Nie,Han Zhang,Jong Seung Kim +16 more
Abstract: Photodynamic therapy (PDT) has been extensively investigated for decades for tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability. It can be a promising treatment modality in several medical fields, including oncology, immunology, urology, dermatology, ophthalmology, cardiology, pneumology, and dentistry. Nevertheless, the clinical application of PDT is largely restricted by the drawbacks of traditional photosensitizers, limited tissue penetrability of light, inefficient induction of tumor cell death, tumor resistance to the therapy, and the severe pain induced by the therapy. Recently, various photosensitizer formulations and therapy strategies have been developed to overcome these barriers. Significantly, the introduction of nanomaterials in PDT, as carriers or photosensitizers, may overcome the drawbacks of traditional photosensitizers. Based on this, nanocomposites excited by various light sources are applied in the PDT of deep-seated tumors. Modulation of cell death pathways with co-delivered reagents promotes PDT induced tumor cell death. Relief of tumor resistance to PDT with combined therapy strategies further promotes tumor inhibition. Also, the optimization of photosensitizer formulations and therapy procedures reduces pain in PDT. Here, a systematic summary of recent advances in the fabrication of photosensitizers and the design of therapy strategies to overcome barriers in PDT is presented. Several aspects important for the clinical application of PDT in cancer treatment are also discussed.
Journal ArticleDOI
Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances.
Chenyang Jia,Yuxin Guo,Fu-Gen Wu +2 more
TL;DR: In this article, the latest advancements in the nanomaterials-involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.
Journal ArticleDOI
ROS-based dynamic therapy synergy with modulating tumor cell-microenvironment mediated by inorganic nanomedicine
TL;DR: Various strategies to modulate tumor cell-microenvironment to enhance the efficacy of DT, by reliving hypoxia, augmenting hydrogen peroxide (H2O2), adjusting the pH, and depleting GSH are summarized.
Journal ArticleDOI
Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy
Panchanathan Manivasagan,Ara Joe,Hyo-Won Han,Thavasyappan Thambi,Manickam Selvaraj,Kumarappan Chidambaram,Jungbae Kim,Eue-Soon Jang +7 more
TL;DR: In this paper , the potential and challenges in the future development of photothermal-enhanced Fenton-based nanocatalytic tumor therapy for clinical application are discussed, and a comprehensive review on this subject is presented.
Journal ArticleDOI
A multimodal strategy of Fe3O4@ZIF-8/GOx@MnO2 hybrid nanozyme via TME modulation for tumor therapy
TL;DR: In this paper, a hybrid nano-zyme for tumor therapy was constructed, which can facilitate the transformation of M2-type macrophages to M1-type, and strong systemic antitumor immune effect was induced.
References
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Progress in multimodal imaging-guided photothermal anti-tumor combined therapy
TL;DR: This review summarizes the recent advances in multimodal imaging-guided PTT and multitherapies in combination with PTT for cancer diagnosis and treatment and effectively overcome the shortcomings of single photothermal anti-tumor therapy.