Journal ArticleDOI
TLC Determination of Strychnine and Brucine of Strychnos nux vomica in Ayurveda and Homeopathy Drugs
TLDR
In this article, a thin layer chromatographic (TLC) method has been developed for the quantitative estimation of the two major alkaloids strychnine and brucine in the plant fruit and in ayurvedic and homeopathic drugs.Abstract:
Strychnos nux vomica is an important plant source for drugs of ayurvedic and homeopathic system of medicine. In this paper a thin layer chromatographic (TLC) method has been developed for the quantitative estimation of the two major alkaloids strychnine and brucine in the plant fruit and in ayurvedic and homeopathic drugs. Chloroform–ethyl acetate–diethyl amine (0.5:8.5:1) as mobile phase gave clear separation with no interference between the bioactive markers. The R
f
values for strychnine and brucine were 0.55 and 0.42. The TLC method was found to be precise, rugged, robust and accurate with recovery of strychnine in the range 93.11–99.82% and brucine 96.95–99.48%. The limit of detection (LOD) and limit of quantification (LOQ) for strychnine were 1.9 and 8.25 ng and for brucine 2.2 and 9.2 ng respectively.read more
Citations
More filters
Journal ArticleDOI
The molecular receptive ranges of human TAS2R bitter taste receptors.
Wolfgang Meyerhof,Claudia Batram,Christian Kuhn,Anne Brockhoff,Elke Chudoba,Bernd Bufe,Giovanni Appendino,Maik Behrens +7 more
TL;DR: The data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs, and some receptors recognized only few agonists, others displayed moderate or extreme tuning broadness.
Journal ArticleDOI
Stability and reactivity study of bio-molecules brucine and colchicine towards electrophile and nucleophile attacks: Insight from DFT and MD simulations
Y. Sheena Mary,Y. Shyma Mary,Stevan Armaković,Sanja J. Armaković,Rohitash Yadav,Ismail Celik,Pratap Mane,Brahmananda Chakraborty,Brahmananda Chakraborty +8 more
TL;DR: In this article, a set of molecular descriptors have been calculated and used in order to identify the most reactive parts of bioactive molecules, brucine (BRU) and colchicine (COL).
Journal ArticleDOI
Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor.
TL;DR: The method was successfully applied for the detection of brucine in traditional pharmaceutical formulations and demonstrated by the analysis of the alkaloid in human serum and urine samples exhibiting considerable potential as a diagnostic tool.
Journal ArticleDOI
An environmentally friendly method to remove and utilize the highly toxic strychnine in other products based on proton-transfer complexation
Abdel Majid A. Adam,Moamen S. Refat,Moamen S. Refat,Hosam A. Saad,Hosam A. Saad,Mohamed S. Hegab,Mohamed S. Hegab +6 more
TL;DR: In this article, a proton-transfer complexation method was used to remove and utilize discarded strychnine (Sy) in other products based on proton transfer complexation.
Journal ArticleDOI
A new method for the simultaneous analysis of strychnine and brucine in Strychnos nux-vomica unprocessed and processed seeds using a carbon-paste electrode modified with multi-walled carbon nanotubes.
TL;DR: A new, sensitive and selective method was developed and successfully applied to the determination of strychnine and brucine in unprocessed and processed Strychnos nux-vomica seed.
References
More filters
Journal ArticleDOI
Zone electrophoresis in open-tubular glass capillaries
Book
Trease and Evans' Pharmacognosy
TL;DR: The scope and practice of pharmacognosy, the study of medicinal plants and animal-derived drugs, and the search for naturally-derived anticancer agents and miscellaneous glycosides are explained.
Book
Clinical Toxicology of Commercial Products
TL;DR: The toxicology of commercial products and its applications are studied in the context of food safety, cosmetics and personal care products.