Journal ArticleDOI
Tocilizumab for severe refractory neuro-Behçet: Three cases IL-6 blockade in neuro-Behçet
TLDR
The data suggest that TCZ may be considered for patients with refractory NBD, and the prednisone dose could successfully be tapered to about 20mg/day, while in another patient glucocorticoids could safely be withdrawn.About:
This article is published in Seminars in Arthritis and Rheumatism.The article was published on 2015-02-01. It has received 70 citations till now.read more
Citations
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Journal ArticleDOI
2018 update of the EULAR recommendations for the management of Behçet’s syndrome
Gulen Hatemi,Robin Christensen,Dongsik Bang,Bahram Bodaghi,Aykut Ferhat Celik,Farida Fortune,Julien Gaudric,Ahmet Gül,Ina Kötter,Pietro Leccese,Alfred Mahr,Robert J. Moots,Yesim Ozguler,Jutta G Richter,David Saadoun,Carlo Salvarani,Francesco Scuderi,Petros P. Sfikakis,Aksel Siva,Miles Stanford,Ilknur Tugal-Tutkun,Richard P. West,Sebahattin Yurdakul,Ignazio Olivieri,Hasan Yazici +24 more
TL;DR: The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added.
Journal ArticleDOI
The Two-Faced Cytokine IL-6 in Host Defense and Diseases
TL;DR: The defensive functions of IL-6 and various pathological conditions are compared and the important role ofIL-6 in host defense should always be kept in mind in clinical practice.
Journal ArticleDOI
Pathogenesis of Behçet’s disease: autoinflammatory features and beyond
TL;DR: Understanding of major histocompatibility complex (MHC) Class I-driven inflammatory response is expected to provide insights for the development of better treatment and remission-induction options in Behçet's disease as well as in ankylosing spondylitis (AS) and psoriasis.
Journal ArticleDOI
Behçet’s disease in children, an overview
TL;DR: BD is a systemic inflammatory disease with a variable vasculitis that carries a strong genetic component and young males have the worst prognosis with significantly more frequent neurological, ocular and vascular involvement.
Journal ArticleDOI
Anti-interleukin 6 receptor tocilizumab in refractory uveitis associated with Behçet's disease: multicentre retrospective study.
Belén Atienza-Mateo,Vanesa Calvo-Río,Emma Beltrán,Lucía Martínez-Costa,Elia Valls-Pascual,Marisa Hernández-Garfella,Antonio Atanes,Miguel Cordero-Coma,Joan M. Nolla,Carmen Carrasco-Cubero,Javier Loricera,María Carmen González-Vela,N. Vegas-Revenga,C. Fernández-Díaz,R. Demetrio-Pablo,L Domínguez-Casas,José Luis Martín-Varillas,Natalia Palmou-Fontana,José L. Hernández,Miguel A. González-Gay,Ricardo Blanco +20 more
TL;DR: TCZ yielded rapid and maintained improvement in all ocular parameters of the patients, with complete remission in eight of them, but this was not the case for the extraocular manifestations, since TCZ was only effective in three of them.
References
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Journal ArticleDOI
The International Criteria for Behçet's Disease (ICBD): A collaborative study of 27 countries on the sensitivity and specificity of the new criteria
Fereydoun Davatchi,Samir H. Assaad-Khalil,Kenneth T. Calamia,J. E. Crook,Bahar Sadeghi-Abdollahi,Michael Schirmer,T. Tzellos,Christos C. Zouboulis,M. Akhlagi,A. Al-Dalaan,Z. S. Alekberova,A. A. Ali,A. Altenburg,E. Arromdee,M. Baltaci,M. Bastos,S. Benamour,I. Ben Ghorbel,Ayşe Boyvat,L. Carvalho,WenChieh Chen,E. Ben-Chetrit,Cheyda Chams-Davatchi,J. A. Correia,J. Crespo,Carlos Tadeu dos Santos Dias,Y. Dong,F. Paixão-Duarte,K. Elmuntaser,A. V. Elonakov,J. Graña Gil,Ali Akbar Haghdoost,R. M. Hayani,Habib Houman,A. R. Isayeva,Ahmadreza Jamshidi,Phaedon G. Kaklamanis,Ashok Kumar,Athanassios Kyrgidis,Wafa Madanat,Abdolhadi Nadji,Kenichi Namba,Shigeaki Ohno,I. Olivieri,J. Vaz Patto,Nicolò Pipitone,M. V. De Queiroz,F. Ramos,C. Resende,C. M. Rosa,Carlo Salvarani,M. J. Serra,Farhad Shahram,Hormoz Shams,Khalifa E. Sharquie,M. Sliti-Khanfir,T. Tribolet De Abreu,C. Vasconcelos,Joana Vedes,Bertrand Wechsler,Y. K. Cheng,Zilong Zhang,N. Ziaei +62 more
TL;DR: Behçet's disease (BD) is a chronic, relapsing, inflammatory vascular disease with no pathognomonic test.
Journal ArticleDOI
Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients. The Neuro-Behçet Study Group.
TL;DR: Parenchymal involvement, elevated protein and/or pleocytosis in the CSF, 'brainstem +' type involvement, primary or secondary progressive course and relapse during steroid tapering were all associated with a poorer prognosis.
Journal ArticleDOI
Physiological and pathological roles of interleukin-6 in the central nervous system.
Donna L. Gruol,T.E. Nelson +1 more
TL;DR: It appears that IL-6 may play a role in both physiological and pathophysiological processes in the CNS, similar to that commonly observed in various neurological diseases.
Journal ArticleDOI
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
TL;DR: A critical role for a proinflammatory cytokine is suggested in the cognitive deficits and associated neuroinflammatory changes that have been documented in neurodegenerative diseases such as Alzheimer disease and AIDS.
Journal ArticleDOI
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis.
Satoshi Serada,Minoru Fujimoto,Masahiko Mihara,Nobuo Koike,Yoshiyuki Ohsugi,Shintaro Nomura,Hiroto Yoshida,Teppei Nishikawa,Fumitaka Terabe,Tomoharu Ohkawara,Tsuyoshi Takahashi,Barry Ripley,Akihiro Kimura,Tadamitsu Kishimoto,Tetsuji Naka +14 more
TL;DR: Findings indicate that anti-IL-6R mAb treatment might represent a novel therapy for human MS through the inhibition of the development of MOG-peptide-specific Th17 cells and Th1 cells, which in turn leads to reduced infiltration of T cells into the CNS.
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H. Vallet,Sophie Rivière,Alice Sanna,Alban Deroux,Guillaume Moulis,Olga Addimanda,Carlo Salvarani,Marc Lambert,Philip Bielefeld,Pascal Sève,Jean Sibilia,Jl Pasquali,J.B. Fraison,Isabelle Marie,Laurent Perard,L. Bouillet,F. Cohen,Damien Sène,Yoland Schoindre,O Lidove,P. Le Hoang,Eric Hachulla,Olivier Fain,Xavier Mariette,Thomas Papo,Bertrand Wechsler,Bahram Bodaghi,M. Resche Rigon,Patrice Cacoub,D. Saadoun +29 more