Journal ArticleDOI
Toward the development of a hepatitis E vaccine.
TLDR
No approved vaccine against hepatitis E is commercially available, but experimental vaccines, based on recombinant proteins derived from the capsid gene of HEV, have been shown efficacious in pre-clinical trials in macaques conferring cross-protection against various genotypes.About:
This article is published in Virus Research.The article was published on 2011-10-01. It has received 49 citations till now. The article focuses on the topics: Hepatitis E & Hepatitis E virus.read more
Citations
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Journal ArticleDOI
Host Immune Status and Response to Hepatitis E Virus Infection
TL;DR: The contributions of altered immune states associated with pregnancy, human immunodeficiency virus [HIV], and immunosuppressive agents used in cancer and transplant medicine to the elevated risks of chronic infection and acute liver failure and mortality are focused on.
Journal ArticleDOI
Hepatitis E: Discovery, global impact, control and cure.
TL;DR: Hepatitis E is an imperative health issue in developing nations, transmitted through sullied water and happens most every now in young adults, the disease is particularly severe during pregnancy and in people with underlying liver cirrhosis.
Journal ArticleDOI
Hepatitis E: an emerging global disease - from discovery towards control and cure.
TL;DR: Hepatitis E is a systemic disease affecting the liver predominantly and caused by infection with the hepatitis E virus, and an estimated one‐third of the world population has been infected with HEV.
Journal ArticleDOI
Liver diseases in pregnancy: diseases unique to pregnancy.
TL;DR: Clinical conditions that are seen only in pregnant women and involve the liver are discussed; from Hyperemesis Gravidarum that happens in 1 out of 200 pregnancies and Intrahepatic Cholestasis of P pregnancy, to the rare entity of Acute Fatty Liver of Pregnancy.
Journal ArticleDOI
Formulation and stabilization of recombinant protein based virus-like particle vaccines.
Nishant Kumar Jain,Neha Sahni,Ozan S. Kumru,Sangeeta B. Joshi,David B. Volkin,C. Russell Middaugh +5 more
TL;DR: Some of the fundamental aspects of formulation design applicable to virus-like-particle based vaccine antigens (VLPs) are described and case studies are presented for commercially approved VLP vaccines as well as some investigational VLP vaccine candidates.
References
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Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
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Study of an epidemic of non-A, non-B, hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type.
TL;DR: The data strongly suggest the possibility of another human hepatitis virus and established the fecal oral route of its spread.
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Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial
Fengcai Zhu,Jun Zhang,Xuefeng Zhang,Cheng Zhou,Zhong-Ze Wang,Shoujie Huang,Hua Wang,Chang-Lin Yang,Han-Min Jiang,Jia-Ping Cai,Yi-Jun Wang,Xing Ai,Yuemei Hu,Quan Tang,Xin Yao,Qiang Yan,Yangling Xian,Ting Wu,Yimin Li,Ji Miao,Mun-Hon Ng,James Wai-Kuo Shih,Ningshao Xia +22 more
TL;DR: HEV 239 is well tolerated and effective in the prevention of hepatitis E in the general population in China, including both men and women age 16-65 years and no vaccination-related serious adverse event was noted.
Journal ArticleDOI
Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants.
Nassim Kamar,Nassim Kamar,Cyril Garrouste,Elizabeth B. Haagsma,Valérie Garrigue,Sven Pischke,Cecile Chauvet,Jérôme Dumortier,Amelie Cannesson,Elisabeth Cassuto-Viguier,Eric Thervet,Filomena Conti,Pascal Lebray,Harry R. Dalton,Robert N. Santella,Nada Kanaan,Marie Essig,Christiane Mousson,Sylvie Radenne,Anne Marie Roque-Afonso,Jacques Izopet,Jacques Izopet,Lionel Rostaing,Lionel Rostaing +23 more
TL;DR: A retrospective analysis of data from 17 centers from Europe and the United States that described the progression, outcomes, and factors associated with development of chronic HEV infection in recipients of transplanted solid organs found tacrolimus therapy is the main predictive factor for chronic hepatitis.
Journal ArticleDOI
Incidence and severity of viral hepatitis in pregnancy.
Mohammad Sultan Khuroo,Mohammed Ramzan Teli,Susan Skidmore,Mohammad Amin Sofi,Mohammad Ismail Khuroo +4 more
TL;DR: A prospective field study was carried out during an epidemic of non-A non-B hepatitis for determining the incidence and severity of hepatitis in pregnant women, nonpregnant women of child bearing age and men and fulminant hepatitis was observed exclusively in the last trimester.