Transbilayer movement of cholesterol in the human erythrocyte membrane.
TLDR
The rate of transbilayer movement of cholesterol was measured in intact human erythrocytes, consistent with an asymmetric distribution of cholesterol in ERYthrocyte membranes, with the majority ofolesterol in the inner leaflet.About:
This article is published in Journal of Lipid Research.The article was published on 1988-04-01 and is currently open access. It has received 101 citations till now. The article focuses on the topics: Cholesterol oxidase & Membrane lipids.read more
Citations
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How Cells Handle Cholesterol
Kai Simons,Elina Ikonen +1 more
TL;DR: The regulation of cholesterol homeostasis is now receiving a new focus, and this changed perspective may throw light on diseases caused by cholesterol excess, the prime example being atherosclerosis.
Journal ArticleDOI
Cellular Cholesterol Efflux Mediated by Cyclodextrins
E. P. C. Kilsdonk,Patricia G. Yancey,Genevieve W. Stoudt,F.W. Bangerter,William J. Johnson,Michael C. Phillips,George H. Rothblat +6 more
TL;DR: The very high efficiency of cyclodextrins in stimulating cell cholesterol efflux suggests that these compounds can be used in two general ways for studies of atherosclerosis: 1) as research tools to probe mechanisms of cholesterol transport and aspects of membrane structure or 2) as potential pharmacological agents that could modify in vivo cholesterol metabolism and influence the development of the atherosclerotic plaque.
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How proteins move lipids and lipids move proteins
TL;DR: It is described here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.
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Cellular Cholesterol Efflux Mediated by Cyclodextrins DEMONSTRATION OF KINETIC POOLS AND MECHANISM OF EFFLUX
Patricia G. Yancey,Wendi V. Rodrigueza,E. P. C. Kilsdonk,Genevieve W. Stoudt,William J. Johnson,Michael C. Phillips,George H. Rothblat +6 more
TL;DR: It seems that cyclodextrin molecules are substantially more efficient than phospholipid acceptors, because cholesterol molecules desorbing from a membrane surface can diffuse directly into the hydrophobic core of a cyclodeXTrin molecule without having to desorb completely into the aqueous phase before being sequestered by the acceptor.
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Cholesterol transport between cells and high-density lipoproteins.
TL;DR: The most prominent and easily measured aspect of sterol movement between HDL and cells is the rapid bidirectional transfer of cholesterol between the lipoprotein and the plasma membrane.
References
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Journal ArticleDOI
Mechanism of cholesterol and phosphatidylcholine exchange or transfer between unilamellar vesicles
L R McLean,M C Phillips +1 more
TL;DR: Results are only consistent with a mechanism of lipid exchange in which cholesterol and phosphatidylcholine diffuse through the aqueous phase; the experimental activation energy is associated with desorption of lipid from the donor bilayer into the aaqueous phase.
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The effect of partial replacements of membrane cholesterol by other steroids on the osmotic fragility and glycerol permeability of erythrocytes
TL;DR: In the presence of 3-ketosteroids, the rates of penetration of glycerol were significantly higher than those containing 3β-hydroxy steroids, and Cholesterol-depleted erythrocytes also exhibited considerably increased Glycerol permeability.
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Analysis of the distribution of cholesterol in the intact cell.
TL;DR: It is demonstrated that an unexpectedly high proportion of cell cholesterol is associated with plasma membranes and that this cholesterol pool can be rapidly and selectively labeled and oxidized, which makes cholesterol a useful specific marker for the plasma membrane.
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The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesis.
J T Gwynne,B Hess +1 more
TL;DR: Results indicate that rat adrenocortical cells possess a specific, saturable, ACTH-dependent mechanism for uptake of HDL cholesterol, suggesting that utilization of LDL cholesterol does not require endocytosis and lysosomal degradation of the entire HDL particle.