Journal ArticleDOI
Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections.
TLDR
The extensive integration and differentiation of in vitro-expanded human neural progenitor cells indicate that multipotent progenitors are capable of responding in a regionally specific manner to cues present in the developing rat brain.About:
This article is published in Experimental Neurology.The article was published on 2002-01-01. It has received 185 citations till now. The article focuses on the topics: Neuroepithelial cell & Neural stem cell.read more
Citations
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Journal ArticleDOI
High efficacy of clonal growth and expansion of adult neural stem cells.
Frank-Peter Wachs,Sebastien Couillard-Despres,Maren Engelhardt,Daniel Wilhelm,Daniel Wilhelm,Sonja Ploetz,Maurice Vroemen,Johanna Kaesbauer,G. Uyanik,Jochen Klucken,Claudia Karl,Johanna Tebbing,Clive N. Svendsen,Norbert Weidner,Hans-Georg Kuhn,Juergen Winkler,Ludwig Aigner +16 more
TL;DR: Efficient growth of adult NSCs in Neurobasal medium containing B27 supplement under clonal and low-density conditions in the absence of serum or conditioned medium is described, providing an important step toward the development of standardized protocols for highly efficient in vitro expansion of N SCs from the adult central nervous system.
Journal ArticleDOI
In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain.
TL;DR: Hypoxic preconditioning and stem cell transplantation have been extensively studied as individual therapies for ischemic stroke and the cell-priming strategy aimed to promote transplanted cell survival and their tissue repair capability provides a simple yet effective way of optimizing cell transplants.
Journal ArticleDOI
Strengths and limitations of the neurosphere culture system.
Josephine B. Jensen,Malin Parmar +1 more
TL;DR: The pros and cons of the neurosphere culture system regarding its three major applications: as an assay for neural stem cells, as a model system for neurogenesis and neural development, and for expansion of Neural stem cells for transplantation purposes are discussed.
Journal ArticleDOI
Angiogenesis-independent tumor growth mediated by stem-like cancer cells.
Per Øystein Sakariassen,Lars Prestegarden,Jian Wang,Kai-Ove Skaftnesmo,Rupavathana Mahesparan,Carla Molthoff,Peter Sminia,Eirik Sundlisæter,Anjan Misra,Berit B. Tysnes,Martha Chekenya,H. Peters,Gabriel Lende,Karl-Henning Kalland,Anne Margrete Øyan,Kjell Petersen,Inge Jonassen,Albert J. van der Kogel,Burt G. Feuerstein,A. Jorge A. Terzis,Rolf Bjerkvig,Per Øyvind Enger +21 more
TL;DR: The described angiogenesis-independent tumor growth and the uncoupling of invasion andAngiogenesis, represented by the stem-like cancer cells and the cells derived from them, respectively, point at two completely independent mechanisms that drive tumor progression.
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Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum.
TL;DR: Human fetal striatum‐ and cortex‐derived NSCs could be considered potentially safe and viable for transplantation, with strong neurogenic potential, for further exploration in animal models of stroke.
References
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Journal ArticleDOI
Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
Journal ArticleDOI
Long-distance neuronal migration in the adult mammalian brain
TL;DR: Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
Journal ArticleDOI
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
TL;DR: An HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted is described, and this multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons.
Journal ArticleDOI
Direct isolation of human central nervous system stem cells
Nobuko Uchida,David W. Buck,Dongping He,Michael J. Reitsma,Marilyn Masek,Thinh V. Phan,Ann Tsukamoto,Fred H. Gage,Irving L. Weissman +8 more
TL;DR: Upon transplantation into brains of immunodeficient neonatal mice, the sorted/expanded hCNS-SC showed potent engraftment, proliferation, migration, and neural differentiation.
Journal ArticleDOI
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
Sang-Hun Lee,Nadya Lumelsky,Lorenz Studer,Lorenz Studer,Jonathan M. Auerbach,Ronald D.G. McKay +5 more
TL;DR: A method for obtaining dopaminergic (DA) and serotonergic neurons in high yield from mouse ES cells in vitro is presented and it is demonstrated that the ES cells can be obtained in unlimited numbers and that these neuron types are generated efficiently.
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