Journal ArticleDOI
Transplanted blood-derived endothelial progenitor cells (EPC) enhance bridging of sheep tibia critical size defects
Nimrod Rozen,Tova Bick,Alon Bajayo,Ben Shamian,Michal Schrift-Tzadok,Yankel Gabet,Avner Yayon,Itai Bab,Michael Soudry,Dina Lewinson +9 more
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TLDR
A critical-sized gap platform was established in sheep tibiae to test whether blood-derived progenitor cells that have endothelial characteristics (EPC) would promote bone regeneration, and on the contrary, EPC transplantation led to formation of dense and massive woven bone all throughout the defect.About:
This article is published in Bone.The article was published on 2009-11-01. It has received 100 citations till now. The article focuses on the topics: Bone regeneration & Transplantation.read more
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Journal ArticleDOI
Role of angiogenesis in bone repair.
TL;DR: The current knowledge elaborating the importance of vascularization during bone healing and remodeling, and the current therapeutic strategies being adapted to promote and improve angiogenesis are reviewed.
Journal ArticleDOI
Endothelial Progenitor Cells and Mesenchymal Stem Cells Seeded onto β-TCP Granules Enhance Early Vascularization and Bone Healing in a Critical-Sized Bone Defect in Rats
Caroline Seebach,Dirk Henrich,Christopher Kähling,Kerstin Wilhelm,Andrea E. Tami,Mauro Alini,Ingo Marzi +6 more
TL;DR: This cell approach suggests that there is a synergistic effect and that the initial stage of neovascularization by EPCs is considered to be crucial for complete bone regeneration in the late phase.
Journal ArticleDOI
Tissue engineering strategies for promoting vascularized bone regeneration
Sarah M. Almubarak,Hubert Nethercott,Marie Freeberg,Caroline Beaudon,Amit K. Jha,Wesley M. Jackson,Ralph S. Marcucio,Theodore Miclau,Kevin E. Healy,Chelsea S. Bahney,Chelsea S. Bahney +10 more
TL;DR: This review addresses the concept of co-culture using osteogenic and vasculogenic stem cells, and how adipose derived stem cells compare to bone marrow derived mesenchymal stem cells in the promotion of angiogenesis.
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Review of vascularised bone tissue‐engineering strategies with a focus on co‐culture systems
TL;DR: The final objective is to generate serious and functional long‐lasting vessels for sustainable angiogenesis that will enable enhanced cellular survival within thick voluminous bone grafts, thereby aiding in bone formation and remodelling in the long term.
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In vivo models of bone repair.
L. A. Mills,A. H. R. W. Simpson +1 more
TL;DR: In this article, the authors performed an extensive literature search of animal models of long bone fracture repair/nonunion and grouped the resulting studies according to the clinical scenario they were attempting to reflect; they then scrutinised them for their reliability and accuracy in reproducing that clinical scenario.
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Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
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Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
Tomono Takahashi,Christoph Kalka,Haruchika Masuda,Donghui Chen,Marcy Silver,Marianne Kearney,Meredith Magner,Jeffrey M. Isner,Takayuki Asahara +8 more
TL;DR: Findings indicate that circulating EPCs are mobilized endogenously in response to tissue ischemia or exogenously by cytokine therapy and thereby augment neovascularization of ischemic tissues.
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Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Carmen Urbich,Stefanie Dimmeler +1 more
TL;DR: This review summarizes the mechanisms regulating endothelial progenitor cell–mediated neovascularization and reendothelialization and describes the characterization of the different progenitors cell populations.
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Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.
Christoph Kalka,Haruchika Masuda,Tomono Takahashi,Wiltrud M. Kalka-Moll,Marcy Silver,Marianne Kearney,Tong Li,Jeffrey M. Isner,Takayuki Asahara +8 more
TL;DR: Ex vivo expanded hEPCs may have utility as a "supply-side" strategy for therapeutic neovascularization in mice with hindlimb ischemia and the rate of limb loss was significantly reduced.
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Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
Edwin M. Horwitz,Darwin J. Prockop,Lorraine A. Fitzpatrick,Winston W.K. Koo,Patricia L. Gordon,Michael D. Neel,Michael D. Sussman,Paul J. Orchard,Jeffrey C. Marx,Reed E. Pyeritz,Malcolm K. Brenner +10 more
TL;DR: Improvements in total body bone mineral content and growth velocity were associated with increases in growth velocity and reduced frequencies of bone fracture, indicating the feasibility of allogeneic bone marrow transplantation in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well.