Journal ArticleDOI
Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
Edwin M. Horwitz,Darwin J. Prockop,Lorraine A. Fitzpatrick,Winston W.K. Koo,Patricia L. Gordon,Michael D. Neel,Michael D. Sussman,Paul J. Orchard,Jeffrey C. Marx,Reed E. Pyeritz,Malcolm K. Brenner +10 more
TLDR
Improvements in total body bone mineral content and growth velocity were associated with increases in growth velocity and reduced frequencies of bone fracture, indicating the feasibility of allogeneic bone marrow transplantation in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well.Abstract:
In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. Here we describe the initial results of allogeneic bone marrow transplantation in three children with osteogenesis imperfecta, a genetic disorder in which osteoblasts produce defective type I collagen, leading to osteopenia, multiple fractures, severe bony deformities and considerably shortened stature. Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. All patients had increases in total body bone mineral content ranging from 21 to 29 grams (median, 28), compared with predicted values of 0 to 4 grams (median, 0) for healthy children with similar changes in weight. These improvements were associated with increases in growth velocity and reduced frequencies of bone fracture. Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well.read more
Citations
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Journal ArticleDOI
Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.
Journal ArticleDOI
Adult rat and human bone marrow stromal cells differentiate into neurons
TL;DR: Adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases.
Journal ArticleDOI
Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.
TL;DR: Harnessing the migratory potential of MSCs by modulating their chemokine‐chemokine receptor interactions may be a powerful way to increase their ability to correct inherited disorders of mesenchymal tissues or facilitate tissue repair in vivo.
Journal ArticleDOI
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.
Amelia Bartholomew,Cord Sturgeon,Mandy Siatskas,Karen Ferrer,Kevin R. Mcintosh,Sheila Patil,Wayne Hardy,S. Devine,David S. Ucker,Robert J. Deans,Annemarie Moseley,Ronald Hoffman +11 more
TL;DR: Baboon MSCs have been observed to alter lymphocyte reactivity to allogeneic target cells and tissues, which may prove useful in future applications of tissue regeneration and stem cell engineering.
Journal ArticleDOI
Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
TL;DR: Bone marrow stromal cells are progenitors of skeletal tissue components such as bone, cartilage, the hematopoiesis‐supporting stroma, and adipocytes and represent an important paradigm of post‐natal nonhematopoietic stem cells, and an easy source for potential therapeutic use.
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