Journal ArticleDOI
tRFs: miRNAs in disguise.
TLDR
The regulatory roles of tRFs in translation, viral infections, and carcinogenesis are discussed, and the miRNAs that overlap with t RFs sequences in humans are catalogued using miRBase.About:
This article is published in Gene.The article was published on 2016-04-01. It has received 79 citations till now. The article focuses on the topics: MiRBase.read more
Citations
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Journal ArticleDOI
Non-Coding RNAs and their Integrated Networks.
TL;DR: This review discusses the distinct types of ncRNAs, including housekeeping n cRNAs and regulatory nc RNAs, their versatile functions and interactions, transcription, translation, and modification, and summarizes the integrated networks of n cRNA interactions, providing a comprehensive landscape of nCRNAs regulatory roles.
Journal ArticleDOI
Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer.
Yuri Pekarsky,Veronica Balatti,Alexey Palamarchuk,Lara Rizzotto,Dario Veneziano,Giovanni Nigita,Laura Z. Rassenti,Harvey I. Pass,Thomas J. Kipps,Chang Gong Liu,Carlo M. Croce +10 more
TL;DR: The results show that tsRNAs are dysregulated in human cancer.
Journal ArticleDOI
Roles of tRNA-derived fragments in human cancers.
Chunxiao Sun,Ziyi Fu,Siwei Wang,Jun Li,Yongfei Li,Yanhong Zhang,Fan Yang,Jiahui Chu,Hao Wu,Xiang Huang,Wei Li,Yongmei Yin +11 more
TL;DR: This review summarizes the biogenesis and biological functions of different subtypes of tRNA-derived fragments and discusses their molecular mechanisms in cancer progression.
Journal ArticleDOI
unitas: the universal tool for annotation of small RNAs.
TL;DR: Unitas as discussed by the authors is an out-of-the-box ready software for complete annotation of small RNA sequence datasets, supporting the wide range of species for which non-coding RNA reference sequences are available in the Ensembl databases.
Journal ArticleDOI
Small Non-Coding RNAs Derived from Eukaryotic Ribosomal RNA
TL;DR: A nonexhaustive list of referenced small non-coding RNAs (ncRNAs) derived from eukaryotic ribosomal RNA (rRNA), called rRNA fragments (rRFs), which will focus on the rRFs that are experimentally verified, and discuss their origin, length, structure, biogenesis, association with known regulatory proteins, and potential role(s) as regulator of gene expression.
References
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Journal ArticleDOI
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
TL;DR: The data suggest that tRFs are not random by-products of tRNA degradation or biogenesis, but an abundant and novel class of short RNAs with precise sequence structure that have specific expression patterns and specific biological roles.
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Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation
Pavel Ivanov,Mohamed Emara,Mohamed Emara,Mohamed Emara,Judit Villén,Steven P. Gygi,Paul A. Anderson,Paul A. Anderson +7 more
TL;DR: The data reveal some of the mechanisms by which stress-induced tRNA cleavage inhibits protein synthesis and activates a cytoprotective stress response program.
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Angiogenin cleaves tRNA and promotes stress-induced translational repression.
TL;DR: It is shown that arsenite, heat shock, or ultraviolet irradiation promotes transfer RNA (tRNA) cleavage and accumulation of tRNA-derived, stress-induced small RNAs (tiRNAs) and angiogenin, a secreted ribonuclease, is required for stress- induced production of tiRNAs.
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Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement
TL;DR: These findings reveal a tumor-suppressive role for specific tRNA-derived fragments and describe a molecular mechanism for their action, which may generalize to other tRNA, ribosomal-RNA, and sno-RNA fragments.
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tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma
Roy Louis Maute,Christof W. Schneider,Pavel Sumazin,Antony B. Holmes,Andrea Califano,Katia Basso,Riccardo Dalla-Favera +6 more
TL;DR: It is demonstrated that one tRNA-derived fragment, cloned from human mature B cells and designated CU1276, in fact possesses the functional characteristics of a microRNA, including a DICER1-dependent biogenesis, physical association with Argonaute proteins, and the ability to repress mRNA transcripts in a sequence-specific manner.