Journal ArticleDOI
Tripartite synapses: astrocytes process and control synaptic information
TLDR
There is an emerging view, which is reviewed herein, in which brain function actually arises from the coordinated activity of a network comprising both neurons and glia, rather than the classically accepted paradigm that brain function results exclusively from neuronal activity.About:
This article is published in Trends in Neurosciences.The article was published on 2009-08-01. It has received 1481 citations till now. The article focuses on the topics: Synaptic plasticity & Tripartite synapse.read more
Citations
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
Neuropathological Alterations in Alzheimer Disease
TL;DR: Postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and the development of diagnostic criteria that are now used worldwide, and these cross-sectional neuropathological data have been largely validated by longitudinal in vivo studies using modern imaging biomarkers such as amyloids PET and volumetric MRI.
Journal ArticleDOI
Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler,Chun-Xia Yi,Ellen A. Schur,Stephan J. Guyenet,Bang H. Hwang,Marcelo O. Dietrich,Xiaolin Zhao,David A. Sarruf,Vitaly Izgur,Kenneth R. Maravilla,Hong T. Nguyen,Jonathan D. Fischer,Miles E. Matsen,Brent E. Wisse,Gregory J. Morton,Tamas L. Horvath,Denis G. Baskin,Matthias H. Tschöp,Michael W. Schwartz +18 more
TL;DR: Obesity is associated with neuronal injury in a brain area crucial for body weight control in both humans and rodent models, and evidence of increased gliosis in the mediobasal hypothalamus of obese humans is found.
Journal ArticleDOI
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Akinobu Suzuki,Sarah A. Stern,Ozlem Bozdagi,George W. Huntley,Ruth H. Walker,Pierre J. Magistretti,Cristina M. Alberini +6 more
TL;DR: It is concluded that astrocyte-neuron lactate transport is required for long-term memory formation, suggesting that lactate import into neurons is necessary for long -term memory.
References
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Book
Principles of Neural Science
TL;DR: The principles of neural science as mentioned in this paper have been used in neural networks for the purpose of neural network engineering and neural networks have been applied in the field of neural networks, such as:
Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Book
Ionic channels of excitable membranes
TL;DR: The Ionic Channel of Excitable Membranes (ICOMB) as discussed by the authors is an extended version of ICOMB with new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology.
Journal ArticleDOI
Tripartite synapses : Glia, the unacknowledged partner
TL;DR: It is suggested that perisynaptic Schwann cells and synaptically associated astrocytes should be viewed as integral modulatory elements of tripartite synapses.
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Astrocytes, from brain glue to communication elements: the revolution continues.
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