Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents
Roberto Romeo,Caterina Carnovale,Salvatore V. Giofrè,Giovanni Romeo,Beatrice Macchi,Caterina Frezza,Francesca Marino-Merlo,Venerando Pistarà,Ugo Chiacchio +8 more
TLDR
Preliminary biological assays show that β-anomers are able to inhibit HIV in vitro infection at concentrations in the micromolar range and higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2012-06-01 and is currently open access. It has received 25 citations till now.read more
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Selective Oxidation of Secondary Amines to N,N-Disubstituted Hydroxylamines by Choline Peroxydisulfate
TL;DR: N,N-disubstituted hydroxylamines were prepared directly from secondary amines by a reliable method using an oxidizing task-specific ionic liquid, choline peroxydisulfate.
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Ene Reaction of Nitrosocarbonyl Mesitylene with the Cinnamyl Alcohol: Metabolic Activity and Apoptosis of the Synthetized 6-Chloropurine N,O-Nucleoside Analogues
Misal Giuseppe Memeo,Elena Valletta,Beatrice Macchi,Alessio Porta,Bruna Bovio,Mattia Moiola,Paolo Quadrelli +6 more
TL;DR: The synthesized 5-acetoxy-isoxazolidine serves as synthon for the preparation of 6-chloropurine N,O-nucleoside analogues, according to the Vorbrüggen reaction.
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Green Synthesis of Novel 5-Arylazo-2-[(2S, 3S, 4R, 5R)-3, 4, 5-Trihydroxy-6-(Hydroxymethyl) Tetrahydro-2H-Pyran-2-Yloxy]-4, 6-Dimethyl 3-Nicotinonitrile
Magda H. Abdellattif,M. M. H. Arief,Adel A.-H. Abdel-Rahman,Abdel-Aleem H. Abdel Aleem,Abdel Moneam Farag Eissa +4 more
TL;DR: In this paper, novel compounds of 5-Arylazo-2-[(substituted)-3, 4, 5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethylnicotinonitrile, (3a-e), generally called (fluroarylazopyridine glucosides) were synthesized via green protocol, microwave.
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A new reporter cell line to monitor HIV infection and drug susceptibility in vitro
Alain Gervaix,Daniel West,Lorenzo M. Leoni,Douglas D. Richman,Flossie Wong-Staal,Jacques Corbeil +5 more
TL;DR: The CEM-GFP reporter cell line provides a simple, rapid, and direct method for monitoring HIV infectivity titers and antiretroviral drug susceptibility of syncytium-inducing strains.
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Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues
TL;DR: Dipartimento Farmaco-Chimico, Università diMessina, Via SS Annunziata, 98168 Messina, Italy, Dipartimenti di Scienze Chimiche, Universidad de Zaragoza, CSIC, and Laboratorio de Sintesis Asimetrica are investigating how Chimiche affects Quimica Organica.
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Halo sugar nucleosides. V. Synthesis of angustmycin A and some base analogues
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Enantioselective Syntheses and Cytotoxicity of N,O-Nucleosides
Ugo Chiacchio,Antonino Corsaro,Daniela Iannazzo,Anna Piperno,Venerando Pistarà,Antonio Rescifina,Roberto Romeo,Vincenza Valveri,Antonio Mastino,Giovanni Romeo +9 more
TL;DR: (5'S)-5-Fluoro-1-isoxazolidin-5-yl-1H-pyrimidine-2,4-dione [(-)-AdFU], while showing low level of cytotoxicity, is a good inductor of apoptosis on lymphoid and monocytoid cells, acting as a strong potentiator of Fas-induced cell death.
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Application of the cycloSal-prodrug approach for improving the biological potential of phosphorylated biomolecules
Chris Meier,Jan Balzarini +1 more
TL;DR: A salicyl alcohol as a cyclic bifunctional masking unit is used, and shown to afford a chemically driven release of the particular nucleotide from the lipophilic phosphate triester precursor molecule.