Tumor endothelial cells.
TLDR
The vascular endothelium is a dynamic cellular "organ" that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes in tumors, which results in endothelial dysfunction.Abstract:
The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In tumors, factors such as hypoxia and chronic growth factor stimulation result in endothelial dysfunction. For example, tumor blood vessels have irregular diameters; they are fragile, leaky, and blood flow is abnormal. There is now good evidence that these abnormalities in the tumor endothelium contribute to tumor growth and metastasis. Thus, determining the biological basis underlying these abnormalities is critical for understanding the pathophysiology of tumor progression and facilitating the design and delivery of effective antiangiogenic therapies.read more
Citations
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Tumor targeting via EPR: Strategies to enhance patient responses
Susanne K. Golombek,Jan Niklas May,Benjamin Theek,Lia Appold,Natascha Drude,Fabian Kiessling,Twan Lammers,Twan Lammers +7 more
TL;DR: Key studies in which systems and strategies to enhance, combine, bypass and image EPR-based tumor targeting, and how these approaches can be employed to enhance patient responses are summarized.
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Tumor microenvironment complexity and therapeutic implications at a glance.
Roghayyeh Baghban,Leila Roshangar,Rana Jahanban-Esfahlan,Khaled Seidi,Abbas Ebrahimi-Kalan,Mehdi Jaymand,Saeed Kolahian,Tahereh Javaheri,Peyman Zare,Peyman Zare +9 more
TL;DR: This review evaluates the dynamic interactions of cancer cells with their microenvironment consisting of stromal cells and extracellular matrix components in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices.
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The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
TL;DR: This review intends to give a contemporary and detailed overview of the different roles of immune cells, exosomes, and molecules acting in the tumor microenvironment and how they relate to immune activation and escape.
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Antibody-drug conjugates as novel anti-cancer chemotherapeutics
Christina Peters,Stuart Brown +1 more
TL;DR: This review summarizes the current knowledge and developments in the field of antibody drug conjugates.
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The extracellular matrix in tumor progression and metastasis.
Johannes A. Eble,Stephan Niland +1 more
TL;DR: This review focuses on the remodeling of the ECM under the influence of a primary solid tumor mass, primed by soluble factors of the primary tumor, which may be remodeled in a way to facilitate the engraftment of metastasizing cancer cells.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
TL;DR: Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.
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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.
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Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.