Journal ArticleDOI
Two-dimensional current source density analysis of propagation delays for components of epileptiform bursts in rat hippocampal slices.
James L. Novak,Bruce C. Wheeler +1 more
TLDR
Differences were found in the apparent propagation delays among 3 burst components: the compound action potential along the Schaffer collaterals, the first population spike directly driven by the CAP, and the second (and succeeding) population spikes representing the bursting, epileptiform component.About:
This article is published in Brain Research.The article was published on 1989-09-18. It has received 29 citations till now. The article focuses on the topics: Population spike & Population.read more
Citations
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Journal ArticleDOI
A three-dimensional multi-electrode array for multi-site stimulation and recording in acute brain slices.
TL;DR: The design and fabrication of planar and 3D protruding multi-electrode arrays for extracellular stimulation and recording from cultured neuronal cells and organotypic brain slices are described and larger signal amplitudes in the millivolt range can be obtained with the 3D electrode devices.
Journal ArticleDOI
A novel organotypic long-term culture of the rat hippocampus on substrate-integrated multielectrode arrays.
Ulrich Egert,Burkhard Schlosshauer,S. Fennrich,Wilfried Nisch,M. Fejtl,Thomas Knott,T. Müller,Hugo Hämmerle +7 more
TL;DR: This is the first realization of hippocampus cultured organotypically on multi-microelectrode arrays for simultaneous recording and electrical stimulation and this biohybrid system promises to become a powerful tool for drug discovery and for the analysis of neural networks, of synaptic plasticity, and of pathophysiological conditions such as ischemia and epilepsy.
Journal ArticleDOI
A flexible perforated microelectrode array for extended neural recordings
TL;DR: A flexible and perforated 32-element planar microelectrode array has been fabricated and used to measure evoked potentials in brain slices and showed an average increase of 10 h to the viability of the slice while using the perforations versus nonperforated arrays.
Journal ArticleDOI
Extracellular recordings from locally dense microelectrode arrays coupled to dissociated cortical cultures.
Luca Berdondini,Paolo Massobrio,Michela Chiappalone,Mariateresa Tedesco,K. Imfeld,Alessandro Maccione,Mauro Gandolfo,Milena Koudelka-Hep,Sergio Martinoia +8 more
TL;DR: Experiments performed on spontaneously active cortical neuronal networks show that spike synchronicity decreases by increasing the time resolution and analysis results show that the detected synchronous spikes on nearby electrodes are likely to be unresolved (in time) fast local propagations, demonstrating the expected gain in detail provided by the spatial resolution.
Journal ArticleDOI
Added astroglia promote greater synapse density and higher activity in neuronal networks.
TL;DR: Results indicate that added astroglia increase the density of synapses and receptors, and facilitate higher spike rates for many elements in the network, which are reproduced by glia-conditioned media, with the exception of glutamate-mediated transmission.
References
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Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Visualization of the spread of electrical activity in rat hippocampal slices by voltage-sensitive optical probes.
TL;DR: Voltage‐sensitive membrane‐bound dyes and a matrix of 100 photodetectors were used to detect the spread of evoked electrical activity at the CA1 region of rat hippocampus slices and a display processor was designed in order to visualize thespread of electrical activity in slow motion.
Journal ArticleDOI
A selective N-methyl-d-aspartate antagonist depresses epileptiform activity in rat hippocampal slices
TL;DR: Intracellular recordings in the presence of bicuculline showed that D-APV reduced the late component of the excitatory postsynaptic potential and the number of action potentials evoked synaptically.
Journal ArticleDOI
Spread of synchronous firing in longitudinal slices from the CA3 region of the hippocampus
TL;DR: Mechanisms underlying the propagation of synchronous epileptiform activity in disinhibited hippocampal slices were examined in experimental and computer simulation studies and the effects of varying synaptic strength and connectivity on the spread of activity in the model was examined.
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