Open AccessJournal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
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TLDR
A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.Abstract:
A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished. Type 1 T helper cells (TH1) produced IL 2, interferon-gamma, GM-CSF, and IL 3 in response to antigen + presenting cells or to Con A, whereas type 2 helper T cells (TH2) produced IL 3, BSF1, and two other activities unique to the TH2 subset, a mast cell growth factor distinct from IL 3 and a T cell growth factor distinct from IL 2. Clones representing each type of T cell were characterized, and the pattern of lymphokine activities was consistent within each set. The secreted proteins induced by Con A were analyzed by biosynthetic labeling and SDS gel electrophoresis, and significant differences were seen between the two groups of T cell line. Both types of T cell grew in response to alternating cycles of antigen stimulation, followed by growth in IL 2-containing medium. Examples of both types of T cell were also specific for or restricted by the I region of the MHC, and the surface marker phenotype of the majority of both types was Ly-1+, Lyt-2-, L3T4+, Both types of helper T cell could provide help for B cells, but the nature of the help differed. TH1 cells were found among examples of T cell clones specific for chicken RBC and mouse alloantigens. TH2 cells were found among clones specific for mouse alloantigens, fowl gamma-globulin, and KLH. The relationship between these two types of T cells and previously described subsets of T helper cells is discussed.read more
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References
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SEROLOGICAL, BIOCHEMICAL, AND FUNCTIONAL IDENTITY OF B CELL-STIMULATORY FACTOR 1 AND B CELL DIFFERENTIATION FACTOR FOR IgG1
Ellen S. Vitetta,J Ohara,Christopher D. Myers,Judith E. Layton,Peter H. Krammer,William E. Paul +5 more
TL;DR: It is demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine and that BSF-1 acts on both resting and activated B cells to induce different effects.
Journal ArticleDOI
Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.
TL;DR: Differences in activation requirements observed for the Lyb-5- and LyB- 5+ B cell subsets do not result from differences in the TH cell populations activating these B cells, but rather reflect differences inThe ability ofThese B cells to respond to signals from the same TH cells.
Journal ArticleDOI
Murine T-cell clones specific for chicken erythrocyte alloantigens.
TL;DR: The specificity pattern suggested that the T-cell clones recognized a more restricted set of cRBC MHC-associated allodeterminants than do antibody-producing cells, which required antigen processing and were MHC restricted and antigen dose dependent.
Journal Article
I-A-controlled T cell molecules: protease sensitivity.
TL;DR: The I-At molecule is shielded by trypsin-labile material on some T cells, whereas on others it is fully exposed, and the transition from a shielded to an exposed configuration may correlate with T cell activation.
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