Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment.
Simona Piccirella,Ibolya Czegle,Beáta Lizák,Éva Margittai,Silvia Senesi,Eszter Papp,Miklós Csala,Miklós Csala,Rosella Fulceri,Peter Csermely,József Mandl,József Mandl,Angelo Benedetti,Gábor Bánhegyi,Gábor Bánhegyi,Gábor Bánhegyi +15 more
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The results demonstrated the separate existence of two redox systems in the endoplasmic reticulum lumen, which explains the contemporary functioning of oxidative folding and of powerful reductive reactions.About:
This article is published in Journal of Biological Chemistry.The article was published on 2006-02-24 and is currently open access. It has received 77 citations till now. The article focuses on the topics: Endoplasmic reticulum & NAD+ kinase.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Endoplasmic reticulum stress.
Gábor Bánhegyi,Peter Baumeister,Angelo Benedetti,Dezheng Dong,Yong Fu,Amy S. Lee,Jianze Li,Changhui Mao,Éva Margittai,Min Ni,Wulf Paschen,Simona Piccirella,Silvia Senesi,Roberto Sitia,Miao Wang,Wei Yang +15 more
TL;DR: The emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes is summarized.
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Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase.
TL;DR: Evidence suggests that ROS production and oxidative stress are not only coincidental to ER stress, but are integral UPR components, being triggered by distinct types of ER stressors and contributing to support proapoptotic, as well as proadaptive UPR signaling.
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ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER
TL;DR: This work has found that an ER-resident protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins, and accelerated ERAD through its physical and functional associations with EDEM (ER degradation–enhancing α-mannosidase–like protein) and anER-resident chaperone BiP.
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Multiple ways to make disulfides
Neil J. Bulleid,Lars Ellgaard +1 more
TL;DR: These various pathways for disulfide formation in the mammalian ER are discussed and the central role played by glutathione is highlighted in regulating this process.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.
Journal ArticleDOI
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
Yuri Kotelevtsev,Megan C. Holmes,Ann Burchell,Pamela Houston,Dieter Schmoll,Pauline Jamieson,Ruth Best,Roger W. Brown,Christopher R. W. Edwards,Jonathan R. Seckl,John J. Mullins +10 more
TL;DR: Attenuation of hepatic 11beta-HSD-1 may provide a novel approach to the regulation of gluconeogenesis, which involves regenerating active glucocorticoids from circulating inert 11-keto forms in specific tissues, notably the liver.
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The fluorometric measurement of pyridine nucleotides.
TL;DR: It has been found practicable with a fluorometer to determine separately oxidized and reduced pyridine nucleotides and the useful range of sensitivity is about 2000-fold, which is much greater than that obtained with calorimetry.