Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death.
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It is shown for the first time that sodium influx can control not only changes in cell size but also the activation of apoptosis, whereas potassium ion loss controls the progression of the cell death process.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-10-03 and is currently open access. It has received 186 citations till now. The article focuses on the topics: Programmed cell death & Intracellular.read more
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Physiology of cell volume regulation in vertebrates.
TL;DR: Current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species are reviewed.
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Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages.
Susan L. Fink,Brad T. Cookson +1 more
TL;DR: This mechanism of caspase‐1‐mediated cell death provides additional experimental evidence supporting pyroptosis as a novel pathway of inflammatory programmed cell death.
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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Xin Chen,Wenjuan Li,Junming Ren,Deli Huang,Wan-ting He,Yunlong Song,Chao Yang,Wanyun Li,Xinru Zheng,Pengda Chen,Jiahuai Han +10 more
TL;DR: Deletion analysis showed that the four-α-helix bundle of MLKL (1-130 amino acids) is sufficient to trigger necroptosis and the homo-oligomerization is required for MLKKL translocation and the signal sequence for plasma membrane location is located in the junction of the first and second α-helices ofMLKL.
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Alterations of intracellular pH homeostasis in apoptosis: origins and roles.
TL;DR: The present review gathers the most recent advances along with previous data on both the origin and the role of pHi alterations in apoptosis and highlights the major concerns that merit further research in the future.
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Technology Insight: water diffusion MRI—a potential new biomarker of response to cancer therapy
TL;DR: The biological basis of observations made on DW-MRI is outlined and how measurements are acquired and quantified are described, and the interpretation of images and limitations of the technique are discussed.
References
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Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
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The biochemistry of apoptosis
TL;DR: The basic components of the death machinery are reviewed, how they interact to regulate apoptosis in a coordinated manner is described, and the main pathways that are used to activate cell death are discussed.
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Biochemical Pathways of Caspase Activation During Apoptosis
TL;DR: This review focuses on the two most well-studied pathways of caspase activation: the cell surface death receptor pathway and the mitochondria-initiated pathway.
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Mechanisms of Caspase Activation and Inhibition during Apoptosis
TL;DR: Current understanding of caspase regulation during apoptosis is presented and structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome are reviewed.
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Morphologic and biochemical hallmarks of apoptosis.
Antti Saraste,Kari Pulkki +1 more
TL;DR: A review of the molecular mechanisms of apoptosis as they relate to the morphologic hallmarks and their implications for the detection of cancer cell apoptosis in cardiac tissue is presented in this article.