Use of Non-Steroidal Anti-Inflammatory Drugs and Prostate Cancer Risk: A Population-Based Nested Case-Control Study
Salaheddin M. Mahmud,Salaheddin M. Mahmud,Eduardo L. Franco,Donna Turner,Robert W. Platt,Patricia Beck,David Skarsgard,Jon Tonita,Colin Sharpe,Armen Aprikian +9 more
TLDR
The findings suggest modest benefits of at least some NSAIDs in reducing prostate cancer risk and there was no clear evidence of dose-response or duration-response relationships for any of the examined NSAID classes.Abstract:
Background
Despite strong laboratory evidence that non-steroidal anti-inflammatory drugs (NSAIDs) could prevent prostate cancer, epidemiological studies have so far reported conflicting results. Most studies were limited by lack of information on dosage and duration of use of the different classes of NSAIDs.
Methods
We conducted a nested case-control study using data from Saskatchewan Prescription Drug Plan (SPDP) and Cancer Registry to examine the effects of dose and duration of use of five classes of NSAIDs on prostate cancer risk. Cases (N = 9,007) were men aged ≥40 years diagnosed with prostatic carcinoma between 1985 and 2000, and were matched to four controls on age and duration of SPDP membership. Detailed histories of exposure to prescription NSAIDs and other drugs were obtained from the SPDP.
Results
Any use of propionates (e.g., ibuprofen, naproxen) was associated with a modest reduction in prostate cancer risk (Odds ratio = 0.90; 95%CI 0.84-0.95), whereas use of other NSAIDs was not. In particular, we did not observe the hypothesized inverse association with aspirin use (1.01; 0.95–1.07). There was no clear evidence of dose-response or duration-response relationships for any of the examined NSAID classes.
Conclusions
Our findings suggest modest benefits of at least some NSAIDs in reducing prostate cancer risk.read more
Citations
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Aspirin and cancer risk: a quantitative review to 2011
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Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
TL;DR: It is suggested that aspirin use is associated with a reduced risk of gastric, esophageal, colorectal, pancreatic, ovarian, endometrial, breast, and prostate cancers, and small intestine neuroendocrine tumors.
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Effect of aspirin and other non-steroidal anti-inflammatory drugs on prostate cancer incidence and mortality: a systematic review and meta-analysis
TL;DR: The present meta-analysis provides support for the hypothesis that aspirin use is inversely related to PCa incidence and PCa-specific mortality.
References
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