Journal ArticleDOI
Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma.
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TLDR
Aberrant or increased expression of cyclooxygenase (COX)‐2 has been implicated in the pathogenesis of many diseases including carcinogenesis and has been shown to be over‐expressed in some human cancers.Abstract:
Aberrant or increased expression of cyclooxygenase (COX)-2 has been implicated in the pathogenesis of many diseases including carcinogenesis. COX-2 has been shown to be over-expressed in some human cancers.
Employing semi-quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry we assessed COX-2 expression in samples of pair-matched benign and cancer tissue obtained from the same prostate cancer patient.
Mean levels of COX-2 mRNA were 3.4-fold higher in prostate cancer tissue (n = 12) compared with the paired benign tissue. The immunoblot analysis demonstrated that as compared to benign tissue COX-2 protein was over-expressed in 10 of 12 samples examined. Immunohistochemical analysis also verified COX-2 over-expression in cancer than in benign tissue.
To our knowledge, this is the first in vivo study showing an over-expression of COX-2 in prostate cancer. These data suggest that COX-2 inhibitors may be useful for prevention or therapy of prostate cancer in humans. Prostate 42:73–78, 2000. © 2000 Wiley-Liss, Inc.read more
Citations
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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
TL;DR: Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.
Journal ArticleDOI
Inflammation and cancer: advances and new agents
TL;DR: It is asserted that inflammation and innate immunity are important targets in patients with cancer on the basis of extensive preclinical and epidemiological data and potential for novel cancer prevention and treatment strategies.
Journal ArticleDOI
Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion
TL;DR: Comparing the effects of PGE2 and PGE3 on cell proliferation in NIH 3T3 fibroblasts, expression and transcriptional regulation of the COX-2 gene in NIH 2-series fibro Blasts, and the production of an inflammatory cytokine, IL-6, in RAW 264.7 macrophages suggests that successful replacement of ω-6 PUFA with ψ-3 PUFA in cell membranes can result in a decreased cellular response to mitogenic
Journal ArticleDOI
Prostate cancer and inflammation: the evidence.
TL;DR: Prostate cancer and inflammation: the evidence and the evidence are summarized and explained in detail.
Journal ArticleDOI
Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer.
Andrew J. Dannenberg,Nasser K. Altorki,Jay O. Boyle,Chau T. Dang,Louise R. Howe,Babette B. Weksler,Kotha Subbaramaiah +6 more
TL;DR: Evidence that cyclooxygenase 2 (COX 2), an inducible form of the enzyme, is a potential pharmacological target to prevent cancer is discussed and key data implicating a causal relation between increased activity of COX 2 and carcinogenesis are implored.
References
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Cyclooxygenases 1 and 2
TL;DR: The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.
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Cyclooxygenase in biology and disease
Raymond N. DuBois,Steven B. Abramson,Leslie J. Crofford,Rajnish A. Gupta,Lee S. Simon,Leo B A van de Putte,Peter E. Lipsky +6 more
TL;DR: The current understanding of the role of cyclooxygenase‐1 and ‐2 in different physiological situations and disease processes ranging from inflammation to cancer is summarized.
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Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
Masanobu Oshima,Joseph E. Dinchuk,Stacia Kargman,Hiroko Oshima,Bruno C. Hancock,Elizabeth Kwong,James M. Trzaskos,Jilly F. Evans,Makoto Mark Taketo,Makoto Mark Taketo +9 more
TL;DR: Results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COx-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer.
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Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells
TL;DR: To explore the role of cyclooxygenase (COX) in endothelial cell migration and angiogenesis, two in vitro model systems involving coculture of endothelial cells with colon carcinoma cells are used.
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Cancer statistics, 1998
TL;DR: The Surveillance Research Program of the American Cancer Society's Department of Epidemiology and Surveillance reports its 32nd annual compilation of cancer incidence, mortality, and survival data for the United States and around the world.