Use of statins and risk of fractures.
TLDR
Use of statins at dosages prescribed in clinical practice was not associated with a reduction in risk of fracture, and use of statin dosage less than 20 mg/d (standardized to simvastatin) was associated with an adjusted OR of fracture.Abstract:
bral fractures, the ORs were 1.01 (95% CI, 0.80-1.27), 0.59 (95% CI, 0.31-1.13), and 1.15 (95% CI, 0.62-2.14), respectively. Relative to nonuse, a statin dosage of less than 20 mg/d (standardized to simvastatin) was associated with an adjusted OR of fracture of 1.13 (95% CI, 0.96-1.33); this OR was 1.07 (95% CI, 0.82-1.38) at dosages of 20 to 39.9 mg/d and 0.85 (95% CI, 0.47-1.53) at dosages of 40 mg/d or more. The adjusted OR was 0.71 (95% CI, 0.50-1.01) for statin use durations of 0 to 3 months, 1.31 (95% CI, 0.87-1.95) for durations of 3 to 6 months, 1.14 (95% CI, 0.82-1.58) for durations of 6 to 12 months, and 1.17 (95% CI, 0.99-1.40) for durations of more than 12 months. Conclusion In this study, use of statins at dosages prescribed in clinical practice was not associated with a reduction in risk of fracture. JAMA. 2001;285:1850-1855 www.jama.comread more
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Gregory R. Mundy,R I Garrett,Stephen E. Harris,J. Chan,David J. Chen,G. Rossini,Brendan F. Boyce,Ming Zhao,Gloria Gutierrez +8 more
TL;DR: It is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents, and may have therapeutic applications for the treatment of osteoporosis.