Journal ArticleDOI
Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis
Nader S. Metwalli,Michael Benatar,Govind Nair,Sharon Usher,Xiaoping Hu,Xiaoping Hu,John D. Carew,John D. Carew,John D. Carew +8 more
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TLDR
Investigating changes in the diffusion tensor imaging measures, axial diffusivity and radialdiffusivity, in patients with amyotrophic lateral sclerosis using the voxel-based statistical analysis tool, tract based spatial statistics found they may be useful diffusion tensors-derived indices to consider in addition to fractional anisotropy and mean diffusiveness to aid in demonstrating neurodegenerative changes.About:
This article is published in Brain Research.The article was published on 2010-08-12. It has received 113 citations till now. The article focuses on the topics: Fractional anisotropy & Thermal diffusivity.read more
Citations
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Mechanisms of white matter changes induced by meditation
TL;DR: This work found that a form of mindfulness meditation, integrative body–mind training (IBMT), improved FA in areas surrounding the anterior cingulate cortex after 4-wk training more than controls given relaxation training, indicating improved efficiency of white matter involves increased myelin as well as other axonal changes.
Journal ArticleDOI
Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders.
TL;DR: The clinical role of DTI in various disease processes such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's dementia, epilepsy, ischemic stroke, stroke with motor or language impairment, traumatic brain injury, spinal cord injury, and depression is summarized.
Journal ArticleDOI
Deep learning predictions of survival based on MRI in amyotrophic lateral sclerosis
Hannelore K. van der Burgh,Ruben Schmidt,Henk Jan Westeneng,Marcel A. de Reus,Leonard H. van den Berg,Martijn P. van den Heuvel +5 more
TL;DR: The findings show the added value of MRI with respect to predicting survival in ALS, demonstrating the advantage of deep learning in disease prognostication.
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Quantitative Tract-Specific Measures of Uncinate and Cingulum in Major Depression Using Diffusion Tensor Imaging
Aifeng Zhang,Alex D. Leow,Olusola Ajilore,Melissa Lamar,Shaolin Yang,Josh W. Joseph,Josh W. Joseph,Jennifer Medina,Liang Zhan,Anand Kumar +9 more
TL;DR: Novel findings of white matter microstructural abnormalities of the right UF of the uncinate fasciculus and cingulum bundle in major depressive disorders are demonstrated, which have implications for both clinical manifestations of depression as well as its pathophysiology.
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Sex differences in white matter development during adolescence: A DTI study
Yingying Wang,Chris Adamson,Weihong Yuan,Mekibib Altaye,Akila Rajagopal,Anna W. Byars,Scott K. Holland,Scott K. Holland +7 more
TL;DR: The results suggest that boys (13-18 years) continued to demonstrate white matter maturation, whereas girls appeared to reach mature levels earlier, and the preliminary evidence presented in this study supports that boys and girls have different developmental trajectories in white matter microstructure.
References
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Advances in functional and structural MR image analysis and implementation as FSL.
Stephen M. Smith,Mark Jenkinson,Mark W. Woolrich,Mark W. Woolrich,Christian F. Beckmann,Behrens Tej.,Heidi Johansen-Berg,Peter R. Bannister,M De Luca,Ivana Drobnjak,D E Flitney,Rami K. Niazy,J Saunders,J Vickers,Yongyue Zhang,N. De Stefano,J M Brady,Paul M. Matthews +17 more
TL;DR: A review of the research carried out by the Analysis Group at the Oxford Centre for Functional MRI of the Brain (FMRIB) on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data.
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A global optimisation method for robust affine registration of brain images
Mark Jenkinson,Stephen M. Smith +1 more
TL;DR: It is demonstrated that the use of local optimisation methods together with the standard multi-resolution approach is not sufficient to reliably find the global minimum, so a global optimisation method is proposed that is specifically tailored to this form of registration.
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Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data.
Stephen M. Smith,Mark Jenkinson,Heidi Johansen-Berg,Daniel Rueckert,Thomas E. Nichols,Clare E. Mackay,Kate E. Watkins,Olga Ciccarelli,M Z Cader,Paul M. Matthews,Timothy E.J. Behrens +10 more
TL;DR: TBSS aims to improve the sensitivity, objectivity and interpretability of analysis of multi-subject diffusion imaging studies by solving the question of how to align FA images from multiple subjects in a way that allows for valid conclusions to be drawn from the subsequent voxelwise analysis.
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Nonparametric permutation tests for functional neuroimaging: A primer with examples
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MR diffusion tensor spectroscopy and imaging.
TL;DR: Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined and the effective diffusivities along these orthotropic directions are the eigenvalues of Deff.