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Journal ArticleDOI

El Escorial revisited : revised criteria for the diagnosis of amyotrophic lateral sclerosis

Benjamin Rix Brooks, +3 more
- 01 Dec 2000 - 
- Vol. 1, Iss: 5, pp 293-299
TLDR
The criteria described below represent the result of a three-day workshop, convened at Airlie Conference Center, Warrenton, Virginia on 2–4 April, 1998 by the World Federation of Neurology Research Committee on Motor Neuron Diseases, and are placed on the WFN ALS website.
Abstract: 
(2000). El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: Vol. 1, No. 5, pp. 293-299.

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Citations
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Journal ArticleDOI

Systematic review of levodopa dose equivalency reporting in Parkinson's disease

Claire L Tomlinson, +5 more
- 15 Nov 2010 - 
TL;DR: A systematic review of studies reporting LEDs yielded a standardized LED for each drug, providing a useful tool to express dose intensity of different antiparkinsonian drug regimens on a single scale.
Journal ArticleDOI

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Jemeen Sreedharan, +20 more
- 21 Mar 2008 - 
TL;DR: The evidence suggests a pathophysiological link between TDP-43 and ALS, and neighboring mutations in a highly conserved region of TARDBP in sporadic and familial ALS cases.
Journal ArticleDOI

The spectrum of disease in chronic traumatic encephalopathy

Ann C. McKee, +25 more
- 01 Jan 2013 - 
TL;DR: The frequent association of chronic traumatic encephalopathy with other neurodegenerative disorders suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the accumulation of other abnormally aggregated proteins including TAR DNA-binding protein 43, amyloid beta protein and alpha-synuclein.
Journal ArticleDOI

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Han Xiang Deng, +26 more
- 08 Sep 2011 - 
TL;DR: Findings link abnormalities in ubiquilin 2 to defects in the protein degradation pathway, abnormal protein aggregation and neurodegeneration, indicating a common pathogenic mechanism that can be exploited for therapeutic intervention.
Journal ArticleDOI

Electrodiagnostic criteria for diagnosis of ALS.

Mamede de Carvalho, +10 more
- 01 Mar 2008 - 
TL;DR: The utility of needle EMG and nerve conduction studies was affirmed and electrophysiological evidence for chronic neurogenic change should be taken as equivalent to clinical information in the recognition of involvement of individual muscles in a limb.
References
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Journal ArticleDOI

Inclusion body myositis. Observations in 40 patients.

B. P. Lotz, +4 more
- 01 Jun 1989 - 
TL;DR: The findings support the notion that IBM is a distinct entity in which a set of pathological features is associated with a constellation of clinical findings, and Prednisone treatment at dose levels frequently effective in polymyositis failed to prevent disease progression in those patients observed for 2 or more years.
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