Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Wen-Wen Yue,Liang Chen,Luodan Yu,Bangguo Zhou,Bangguo Zhou,Haohao Yin,Haohao Yin,Wei-Wei Ren,Chang Liu,Le-Hang Guo,Yi-Feng Zhang,Li-Ping Sun,Kun Zhang,Hui-Xiong Xu,Yu Chen +14 more
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TLDR
A nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy is used, and it is found that when used together with anti-PD-L1, tumour formation and metastases are impacted.Abstract:
Combined checkpoint blockade (e.g., PD1/PD-L1) with traditional clinical therapies can be hampered by side effects and low tumour-therapeutic outcome, hindering broad clinical translation. Here we report a combined tumour-therapeutic modality based on integrating nanosonosensitizers-augmented noninvasive sonodynamic therapy (SDT) with checkpoint-blockade immunotherapy. All components of the nanosonosensitizers (HMME/R837@Lip) are clinically approved, wherein liposomes act as carriers to co-encapsulate sonosensitizers (hematoporphyrin monomethyl ether (HMME)) and immune adjuvant (imiquimod (R837)). Using multiple tumour models, we demonstrate that combining nanosonosensitizers-augmented SDT with anti-PD-L1 induces an anti-tumour response, which not only arrests primary tumour progression, but also prevents lung metastasis. Furthermore, the combined treatment strategy offers a long-term immunological memory function, which can protect against tumour rechallenge after elimination of the initial tumours. Therefore, this work represents a proof-of-concept combinatorial tumour therapeutics based on noninvasive tumours-therapeutic modality with immunotherapy.read more
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Multifunctional sonosensitizers in sonodynamic cancer therapy
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TL;DR: This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy and the potential ofSDT in combination with other modalities to address unmet needs in precision medicine.
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Mengyu Chang,Mengyu Chang,Man Wang,Meifang Wang,Meifang Wang,Mengmeng Shu,Binbin Ding,Binbin Ding,Chunxia Li,Maolin Pang,Shuzhong Cui,Zhiyao Hou,Jun Lin,Jun Lin +13 more
TL;DR: The PEGylated CMS@GOx‐based synergistic therapy combined with checkpoint blockade therapy could elicit robust immune responses for both effectively ablating primary tumors and inhibiting cancer metastasis.
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Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy
Xianwen Wang,Xiaoyan Zhong,Lixin Bai,Jun Xu,Fei Gong,Ziliang Dong,Zhijuan Yang,Zhijie Zeng,Zhuang Liu,Liang Cheng +9 more
TL;DR: This work highlights a new type of titanium-based nanostructure with great performance for tumor SDT, PEG-TiO1+x NRs, which can be used as a sono-sensitizer and CDT agent for highly effective tumor ablation under US treatment.
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Recent Advances in Nanomaterial-Assisted Combinational Sonodynamic Cancer Therapy.
Shuang Liang,Shuang Liang,Xiaoran Deng,Ping'an Ma,Ping'an Ma,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +8 more
TL;DR: The design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted and the ultimate goals are to stimulate the design of better‐quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.
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Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer.
TL;DR: In this paper, a photothermally activatable polymeric pro-nanoagonist (APNA) was constructed from covalent conjugation of an immunostimulant onto a NIR-II semiconducting transducer through a labile thermo-responsive linker, which not only triggers tumor ablation and immunogenic cell death but also initiates the cleavage of thermolabile linker to liberate caged agonist for in-situ immune activation in deep solid tumor (8 mm).
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