Journal ArticleDOI
Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations
Janneke Jentink,Maria Loane,Helen Dolk,Ingeborg Barišić,Ester Garne,Joan K. Morris,Lolkje T. W. de Jong-van den Berg +6 more
TLDR
The use of valproic acid monotherapy in the first trimester of pregnancy was associated with significantly increased risks of several congenital malformations, as compared with no use of antiepileptic drugs or with use of other antiespecific drugs.Abstract:
Background The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited. Methods We first combined data from eight published cohort studies (1565 pregnancies in which the women were exposed to valproic acid, among which 118 major malformations were observed) and identified 14 malformations that were significantly more common among the offspring of women who had received valproic acid during the first trimester. We then assessed the associations between use of valproic acid during the first trimester and these 14 malformations by performing a case–control study with the use of the European Surveillance of Congenital Anomalies (EUROCAT) antiepileptic-study database, which is derived from population-based congenital-anomaly registries. Registrations (i.e., pregnancy outcomes with malformations included in EUROCAT) with any of these 14 malformations were compared with two control groups, o...read more
Citations
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Cleft lip and palate: understanding genetic and environmental influences.
TL;DR: Using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP.
Journal ArticleDOI
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013.
Lakshmi N. Yatham,Sidney H. Kennedy,Sagar V. Parikh,Ayal Schaffer,Serge Beaulieu,Martin Alda,Claire O'Donovan,Glenda MacQueen,Roger S. McIntyre,Verinder Sharma,Arun V. Ravindran,L. Trevor Young,Roumen Milev,David J. Bond,Benicio N. Frey,Benjamin I. Goldstein,Beny Lafer,Boris Birmaher,Kyooseob Ha,Willem A. Nolen,Michael Berk,Michael Berk +21 more
TL;DR: The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009, and this third update, in conjunction with the International Society for Bipolar Disorders, reviews new evidence and is designed to be used in conjunctionWith the previous publications.
Journal ArticleDOI
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder
Lakshmi N. Yatham,Sidney H. Kennedy,Sagar V. Parikh,Ayal Schaffer,David J. Bond,Benicio N. Frey,Verinder Sharma,Benjamin I. Goldstein,Soham Rej,Serge Beaulieu,Martin Alda,Glenda MacQueen,Roumen Milev,Arun V. Ravindran,Claire O'Donovan,Diane McIntosh,Raymond W. Lam,Gustavo Vazquez,Flávio Kapczinski,Roger S. McIntyre,Jan Marie Kozicky,Shigenobu Kanba,Beny Lafer,Trisha Suppes,Joseph R. Calabrese,Eduard Vieta,Gin S Malhi,Robert M. Post,Michael Berk +28 more
TL;DR: These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments.
Journal ArticleDOI
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Jakob Christensen,Therese Koops Grønborg,Merete Juul Sørensen,Diana Schendel,Erik T. Parner,Lars Pedersen,Mogens Vestergaard +6 more
TL;DR: Maternal use of valproate during pregnancy was associated with a significantly increased risk of autism spectrum disorder and childhood autism in the offspring, even after adjusting for maternal epilepsy.
Journal ArticleDOI
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009.
Lakshmi N. Yatham,Sidney H. Kennedy,Ayal Schaffer,Sagar V. Parikh,Serge Beaulieu,Claire O'Donovan,Glenda MacQueen,Roger S. McIntyre,Verinder Sharma,Arun V. Ravindran,L. Trevor Young,Allan H. Young,Martin Alda,Roumen Milev,Eduard Vieta,Joseph R. Calabrese,Michael Berk,Kyooseob Ha,Flávio Kapczinski +18 more
TL;DR: New data support the use of quetiapine monotherapy and adjunctive therapy for the Prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long-acting injection monotherapy
References
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Journal ArticleDOI
Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register
Ji Morrow,Aline Russell,Eleanor Guthrie,L. Parsons,I. Robertson,R. Waddell,B. Irwin,R.C. McGivern,Patrick J. Morrison,John Craig +9 more
TL;DR: Only 4.2% of live births to women with epilepsy had an MCM, and polytherapy exposure was greater than for monotherapy exposure, and carbamazepine was associated with the lowest risk of MCM.
Journal ArticleDOI
Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs
Kimford J. Meador,Gus A. Baker,Nancy Browning,Jill Clayton-Smith,Deborah T. Combs-Cantrell,Morris J. Cohen,Laura A. Kalayjian,Andres M. Kanner,Joyce Liporace,Page B. Pennell,Michael Privitera,David W. Loring +11 more
TL;DR: In utero exposure to valproate, as compared with other commonly used antiepileptic drugs, is associated with an increased risk of impaired cognitive function at 3 years of age, and this finding supports a recommendation thatValproate not be used as a first-choice drug in women of childbearing potential.
Journal ArticleDOI
Maternal valproic acid and congenital neural tube defects
Elisabeth Robert,Pierre Guibaud +1 more
Journal ArticleDOI
Maternal use of antiepileptic drugs and the risk of major congenital malformations : A joint European prospective study of human teratogenesis associated with maternal epilepsy
E. B. Samren,C M van Duijn,S Koch,V K Hiilesmaa,H. Klepel,A H Bardy,G B Mannagetta,A W Deichl,Eija Gaily,Marja-Liisa Granström,H. Meinardi,D. E. Grobbee,A. Hofman,D. Janz,Dick Lindhout +14 more
TL;DR: The objective was to quantify the risks of intrauterine antiepileptic drug (AED) exposure in monotherapy and poly‐therapy and to assess the importance of knowing the carrier and removal status of these drugs.
Journal ArticleDOI
Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society
Cynthia L. Harden,Kimford J. Meador,Page B. Pennell,W. A. Hauser,Gary S. Gronseth,Jacqueline A. French,S. Wiebe,David J. Thurman,Barbara S. Koppel,Peter W. Kaplan,Julian N. Robinson,Jennifer L. Hopp,Tricia Y. Ting,Barry E. Gidal,Collin A. Hovinga,Andrew Wilner,B. Vazquez,Lewis B. Holmes,Allan Krumholz,Richard H. Finnell,Deborah Hirtz,C. Le Guen +21 more
TL;DR: Reassessment of evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy finds it highly probable that intrauterine first-trimester valproate (VPA) exposure has higher risk of major congenital malformations (MCMs) compared to carbamazepine and possible compared to phenytoin or lamotrigine.