Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery
Ah Young Leem,Moo Suk Park,Byung Hoon Park,Won Jai Jung,Kyung Soo Chung,Song Yee Kim,Eun Young Kim,Ji Ye Jung,Young Ae Kang,Young Sam Kim,Se Kyu Kim,Joon Chang,Joo Han Song +12 more
TLDR
Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis in patients withSeverely ill patients admitted to the intensive care unit (ICU) were included.Abstract:
PURPOSE Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. MATERIALS AND METHODS Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. RESULTS Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58-144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00-2.68, p=0.048) were associated with recovery of AKI. CONCLUSION Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.read more
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Novel acute kidney injury biomarkers: their characteristics, utility and concerns
TL;DR: Novel biomarkers seem to be more helpful to early detect AKI and/or predict the need for renal replacement, and mortality compared to serum creatinine, but more comprehensive studies are still required to determine their clinical utility.
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TL;DR: The results indicate that women are exposed to AFB1, due to the fact that the AFB1-Lys biomarker was found in a high percentage of the study population (83%) and show a strong significant correlation between KIM-1 and Cys-C that may indicate the toxic renal effect.
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Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis.
Justyna Wajda,Paulina Dumnicka,Małgorzata Maraj,Piotr Ceranowicz,Marek Kuźniewski,Beata Kuśnierz-Cabala +5 more
TL;DR: The aim of the study was to review current evidence on the laboratory tests that were studied as the potential biomarkers of AKI in AP and to summarized the knowledge coming from the studies including sepsis or ICU patients since severe acute pancreatitis is associated with systemic inflammation and organ failure.
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A combination of SOFA score and biomarkers gives a better prediction of septic AKI and in-hospital mortality in critically ill surgical patients: a pilot study
Chao-Wei Lee,Chao-Wei Lee,Hao-Wei Kou,Hong-Shiue Chou,Hsu-huan Chou,Song-Fong Huang,Chih-Hsiang Chang,Chun-Hsing Wu,Ming-Chin Yu,Ming-Chin Yu,Hsin-I Tsai,Hsin-I Tsai +11 more
TL;DR: This pilot study demonstrated a promising panel that allows an early diagnosis, high sensitivity, and specificity and a prognostic value for septic AKI and in-hospital mortality in surgical ICU.
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An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality.
Alice Cambiaghi,R. Díaz,Julia Bauzá Martinez,Antonia Odena,Laura Brunelli,Pietro Caironi,Serge Masson,Giuseppe Baselli,Giuseppe Ristagno,Luciano Gattinoni,Eliandre de Oliveira,Roberta Pastorelli,Manuela Ferrario +12 more
TL;DR: Looking at the variable importance (VIP) and the selected features, the integration of metabolomics with proteomics data showed the importance of circulating lipids and coagulation cascade in septic shock progression, thus capturing a further layer of biological information complementary to metabolomics information.
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