Virology, Epidemiology, Pathogenesis, and Control of COVID-19.
Yuefei Jin,Haiyan Yang,Wangquan Ji,Weidong Wu,Shuaiyin Chen,Weiguo Zhang,Weiguo Zhang,Guangcai Duan +7 more
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TLDR
The present understanding of COVID-19 is detailed and the current state of development of measures are introduced in this review to provide a comprehensive summary to public health authorities and potential readers worldwide.Abstract:
The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. To provide a comprehensive summary to public health authorities and potential readers worldwide, we detail the present understanding of COVID-19 and introduce the current state of development of measures in this review.read more
Citations
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SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial
Monika Tandon,Wen Wu,Keith Moore,Stephen Winchester,Yuan-Po Tu,Chris Miller,Rahul Kodgule,Amol Pendse,Shabbir Rangwala,Shashank Joshi +9 more
TL;DR: In this paper , a randomized, double-blind, multicentre, parallel group, placebo-controlled phase III clinical trial evaluated the ability of nitric oxide (NO) to rapidly eradicate nasal SARS-CoV-2 RNA.
Journal ArticleDOI
A preliminary study on contact tracing & transmission chain in a cluster of 17 cases of severe acute respiratory syndrome coronavirus 2 infection in Basti, Uttar Pradesh, India.
TL;DR: A cluster of 17 cases including one death of confirmed COVID-19 in Basti, UP, India, and the funeral acted as a super-spreader event for the transmission of infection among family members, relatives and others led to the isolation of 16 SARS-CoV-2 positive cases and hence the limited spread of the disease.
Journal ArticleDOI
Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination Strategies
Matthaios Speletas,I. Voulgaridi,Styliani Sarrou,Aikaterini Dadouli,Varvara A. Mouchtouri,Dimitrios J. Nikoulis,M. Tsakona,Maria Kyritsi,Athanasia-Marina Peristeri,Ioanna Avakian,Asimina Nasika,Paraskevi C. Fragkou,Charalampos D. Moschopoulos,Stamatia Zoubouneli,I. Onoufriadis,Lemonia Anagnostopoulos,Alexia Matziri,G. Papadamou,Aikaterini T Theodoridou,Sotirios Tsiodras,Christos Hadjichristodoulou +20 more
TL;DR: It was found that only a medical history of autoimmune disease could affect the intensity of IgA and IgG responses (3 weeks after the primary and secondary immunization, respectively), while development of systemic adverse reactions after the second vaccination dose was significantly associated with the height of IgG responds.
Journal ArticleDOI
Prolonged Oxygen Therapy Post COVID-19 Infection: Factors Leading to the Risk of Poor Outcome
Alokananda Ray,Rajan Chaudhry,Sudhir Rai,Sujata Mitra,Sridhar Pradhan,Ashok Sunder,Deb Sanjay Nag +6 more
TL;DR: In this article, the authors describe the epidemiological, clinical and imaging characteristics of hospitalised patients of COVID-19 who required prolonged oxygen therapy after testing negative for SARS-CoV-2 and attempt to determine the associated factors leading to delayed recovery, failure to wean, and mortality.
Journal ArticleDOI
Anticoagulation Prior to COVID-19 Infection Has No Impact on 6 Months Mortality: A Propensity Score–Matched Cohort Study
Marcin Protasiewicz,Konrad Reszka,Wojciech Kosowski,Barbara Adamik,Wojciech Bombała,Adrian Doroszko,Damian Gajecki,Jakub Gawrys,Maciej Guziński,Maria Jędrzejczyk,Krzysztof Kaliszewski,Katarzyna Kiliś-Pstrusińska,Bogusława Konopska,Agnieszka Kopec,Krzysztof Kujawa,Anna Langner,A. Larysz,Weronika Lis,Lilla Pawlik-Sobecka,Joanna Górka-Dynysiewicz,Marta Rosiek-Biegus,Agnieszka Matera-Witkiewicz,Tomasz Matys,Michał Pomorski,Mateusz Sokolski,Janusz Sokołowski,Anna Tomasiewicz-Zapolska,Katarzyna Madziarska,Ewa A. Jankowska +28 more
TL;DR: It is suggested that antithrombotic treatment prior to CO VID-19 infection is unlikely to be protective for morbidity and mortality in patients hospitalized with COVID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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